PMID: 6628498Jan 1, 1983

Comparative haemodynamic dose-response effects of intravenous propranolol and pindolol in patients with coronary heart disease

European Journal of Clinical Pharmacology
B SilkeS H Taylor

Abstract

To determine whether the depression of left ventricular pumping activity associated with beta-blockade alone could be offset by a substantial degree of partial agonist activity, the haemodynamic dose-response effects of intravenous propranolol and pindolol were compared in a randomised between-group saline controlled study in twenty patients with angiographically proven coronary artery disease. The intravenous doses of propranolol (2-16 mg) and pindolol (0.2-1.6 mg) used were selected on the basis of published reports of equivalence in terms of exercise blockade of chronotropic beta-adrenoceptors. Following four intravenous boluses of each drug, administered according to a cumulative log-dosage schedule, there was a log-linear increase in the plasma concentrations of each drug. The range of plasma concentrations achieved were those which have been shown to be associated with substantial attenuation of sympathetic stimulation of cardiac beta-adrenoceptors. At rest propranolol resulted in dose-related linear reductions in heart rate and cardiac output and linear increases in left heart filling pressure and systemic vascular resistance compared with saline-controlled measurements. The only statistically significant change at rest ...Continue Reading

References

Jan 1, 1981·European Journal of Clinical Pharmacology·W G HendryS H Taylor
Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Oct 1, 1984·American Heart Journal·A J Wood
Aug 1, 1987·Journal of Clinical Pharmacology·J AskenaziA Laddu

Citations

May 21, 1979·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Oct 31, 1970·Lancet·B Sharma, S H Taylor
Apr 1, 1971·Experimental Parasitology·A J SulzerE C Hall
Jul 11, 1972·The American Journal of Cardiology·L LembergD Slavin
May 1, 1972·Cardiovascular Research·L J PelidesJ P Shillingford
Jan 30, 1971·British Medical Journal·G Sandler, A C Pistevos
Oct 1, 1980·British Journal of Clinical Pharmacology·R GuglerG Bodem
Jun 1, 1981·Clinical Pharmacology and Therapeutics·T L SvendsenJ Bliddal
Jan 1, 1982·British Journal of Clinical Pharmacology·O ThulesiusE Berlin
Nov 18, 1982·The New England Journal of Medicine·S H TaylorD M Burley
Apr 2, 1981·The New England Journal of Medicine·Norwegian Multicenter Study Group
Nov 6, 1981·JAMA : the Journal of the American Medical Association
Jan 1, 1982·British Journal of Clinical Pharmacology·B J ClarkA Bertholet
Jan 1, 1982·British Journal of Clinical Pharmacology·S G Carruthers

Related Concepts

Visken
Total Peripheral Resistance
Coronary Artery Disease
Systolic Blood Pressure Measurement
Intravenous Injections
Coronary Arteriosclerosis
Left Side of Heart
Angina Pectoris
Pindolol
Adrenergic Receptor

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