Abstract
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated. Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs. With the doses used, the inotropic effects of both drugs are similar, while the chronotropic action is statistically higher during isoprenaline infusion than after glucagon administration. This fact explains the greater increase in cardiac index after isoprenaline administration. Mean arterial pressure shows no significant changes after either drug, while right atrial mean pressure decreases significantly. Peripheral vascular resistance remained mostly constant. The activity of glucagon injected as a single bolus seems to be maximal 10 to 15 minutes after the injection and dissipates about 30 minutes later. The ideal dose of isoprenaline is between 0.8 and 2 mug/min. Within this range, the inotropic effect is maximal and the chronotropic and bathmotropic effects are limited. Above 2 mug/min, cardiac index and stroke index decrease, and arrhy...Continue Reading
References
Feb 1, 1969·Circulation Research·G S Levey, S E Epstein
Jun 1, 1971·Circulation·R A PolumboA M Weissler
May 1, 1972·Circulation·R M Gunnar, H S Loeb
Jan 1, 1973·Cardiovascular Research·A C VliersW G Zijlstra
May 1, 1973·Cardiovascular Research·B S JenkinsR D Bradley
Jul 4, 1968·The New England Journal of Medicine·W W ParmleyE H Sonnenblick
Feb 1, 1972·Toxicology and Applied Pharmacology·T BalazsJ F Noble
Mar 1, 1971·The American Journal of Cardiology·W W Parmley, E H Sonnenblick
Apr 1, 1968·Circulation·H MuellerJ J Gregory
Jun 1, 1968·Circulation Research·G GlickE H Sonnenblick
Nov 1, 1968·The American Journal of Cardiology·J W LinhartP Samet
May 1, 1969·Circulation·W W ParmleyE H Sonnenblick
Oct 24, 1966·Biochimica Et Biophysica Acta·L A WaskellM P Gordon
Feb 1, 1967·Circulation·J S CareyW C Shoemaker
Jun 1, 1967·Circulation·H J SmithM McGregor
Apr 1, 1967·Cardiovascular Research·R M Fordham, L Resnekov
Jul 1, 1964·American Heart Journal·V J FERRANSD G WEILBAECHER
Aug 28, 1965·Lancet·M J GREENBERG