PMID: 6202976May 1, 1984

Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide

Journal of Cardiovascular Pharmacology
J BeltrameJ P Chalmers

Abstract

The effect of intravenous boluses of lidocaine (5 mg/kg), mexiletine (3.5 mg/kg), and disopyramide (5 mg/kg) on mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), total peripheral resistance, left ventricular end-diastolic pressure, and peak rate of change of left ventricular pressure (peak LV dP/dt) were assessed in the conscious rabbit. Plasma levels for the three drugs corresponded to the human therapeutic range 3 min after administration. All three drugs had negative inotropic effects and reduced HR. Lidocaine reduced peak LV dP/dt by 26%, mexiletine by 41%, and disopyramide by 53%. The three drugs had quite different effects on CO as a result of differences in their actions on peripheral blood vessels: disopyramide caused a 21% fall in CO, associated with a significant vasoconstriction; mexiletine did not lower CO, as it caused a substantial vasodilation; and lidocaine did not produce any substantial change in either CO or vascular resistance. Cardiac autonomic blockade did not alter these changes. These results confirm that disopyramide has a marked cardiodepressant effect, and demonstrate that, although lidocaine depresses myocardial contractility in the conscious rabbit, it has little effect on other ha...Continue Reading

Citations

Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·S R Tella
Nov 15, 1989·Journal of the American College of Cardiology·B Surawicz
Dec 1, 1990·British Journal of Pharmacology·N KondoS Shibata
Mar 1, 1994·British Journal of Pharmacology·Y DohiK Sato
May 20, 2005·American Journal of Veterinary Research·Bruno H Pypendop, Jan E Ilkiw
Feb 1, 1987·Pharmacology & Toxicology·J BondeL E Pedersen

Related Concepts

Diastolic Blood Pressure
Cardiac Output
Disopyramide, L-Tartrate, (S)-isomer
Pulse Rate
Hemodynamics
Lidocaine Monohydrochloride, Monohydrate
Novo-Mexiletine
Propylamines
Pulmonary Vascular Resistance

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.