PMID: 11922403Apr 2, 2002Paper

Comparative haemodynamic responses to the first dose of short- and long-acting ACE inhibitors in patients with congestive heart failure

Current Medical Research and Opinion
L AnthopoulosS Zombolos

Abstract

Angiotensin Converting Enzyme inhibitors (ACEi's) confer significant mortality and morbidity benefits in all functional grades of chronic heart failure (CHF). However, physicians' concerns regarding the possible occurrence of first-dose hypotension appear to be a contributing factor to their under-utilisation in both hospital and primary care settings. We investigated whether long-acting and short-acting ACEi's differ in their haemodynamic responses to the first-dose in patients with CHF. This was a multicentre, randomised, open, two-parallel-group study of captopril 6.25 mg and perindopril 2 mg. 240 patients with CHF, age 68.9 +/- 8.9 years, of whom 66% were male, NYHA II-IV, with average blood pressure baseline values of 132.2 +/- 16.2/78.5 +/- 10.5 mmHg for systolic and diastolic blood pressure, and left ventricular ejection fraction (LVEF) of 31.3 +/- 7.4% received either captopril (n = 124) or perindopril (n = 116). Blood pressure was continuously monitored during the 8 h following drug intake. Minimum levels and maximum decreases in systolic, diastolic and mean arterial pressures were measured, along with the incidence of hypotensive episodes defined as mean blood pressure (MBP) fall > 20 mmHg, whether symptomatic or not....Continue Reading

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Citations

Dec 3, 2014·Pharmacological Reports : PR·Krzysztof LukawskiStanisław J Czuczwar
May 1, 2008·Future Cardiology·Ahmed Zaiem, Faiez Zannad
Jan 30, 2015·Journal of Human Hypertension·C Di StefanoF Veglio
Jun 22, 2002·Drugs·Dene SimpsonKaren L Goa
Sep 8, 2020·Drugs & Aging·Giulia RivasiAndrea Ungar

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