Comparative hemodynamic effects of three different parenterally administered lipid emulsions in conscious dogs

Critical Care Medicine
M Van de VeldeE Vandermeersch

Abstract

To compare the hemodynamic side effects of three structurally different lipid emulsions. Randomized, controlled, prospective animal study. University research laboratory. Six chronically instrumented mongrel dogs. On separate days, all animals were submitted to three different treatments, in a randomized order. After baseline measurements, either a long-chain triglyceride emulsion (treatment 1), a mixed medium-chain triglyceride/long-chain triglyceride emulsion (treatment 2), or an omega3 polyunsaturated fatty acid long-chain triglyceride (PUFA) emulsion (treatment 3) was administered intravenously over 30 mins. Global and regional hemodynamics (sonomicrometry) were recorded for 2 hrs after baseline measurements. Arterial blood gases and plasma concentrations of hemoglobin, triglycerides, total protein, and glucose were recorded for 2 hrs. Long-chain triglycerides did not affect the cardiovascular performance in awake animals. However, medium-chain triglycerides/long-chain triglycerides and omega3 PUFA caused marked increases in systemic vascular resistance (from 1833 +/- 154 to 3277 +/- 163 mm Hg/dynexsec5, p < .05), heart rate (from 89 +/- 6 to 158 +/- 10 beats/min, p < .05), and depressed ventricular performance (wall-thicke...Continue Reading

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Citations

Mar 11, 2010·Regional Anesthesia and Pain Medicine·Guy L Weinberg
Oct 31, 2014·Journal of the American Veterinary Medical Association·Martin J Kennedy, Lesley J Smith
May 10, 2013·Journal of Veterinary Emergency and Critical Care·Barbara L MatonAmy J Alwood
Aug 11, 2011·Journal of Veterinary Emergency and Critical Care·Alberto L FernandezKristin Engebretsen
Mar 30, 2016·Nitric Oxide : Biology and Chemistry·Kurt VranckenArlin B Blood
Aug 15, 2015·BioMed Research International·Seong-Ho OkJu-Tae Sohn
May 1, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·V E SmyrniotisJ G Vassiliou
Jan 23, 2018·Regional Anesthesia and Pain Medicine·Michael R Fettiplace, Guy Weinberg
Mar 8, 2020·International Journal of Molecular Sciences·Soo Hee LeeJu-Tae Sohn
Dec 17, 2019·Dose-response : a Publication of International Hormesis Society·Soo Hee LeeJu-Tae Sohn
Feb 12, 2009·Bioconjugate Chemistry·Eishun TsuchidaKoichi Kobayashi

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