Comparative Histologic and Molecular Analysis of 2 Recurrent Lesions Showing Different Magnetic Resonance Imaging Responses After Bevacizumab Treatment: Report of a Case of Anaplastic Astrocytoma

World Neurosurgery
Yoshihiro OtaniIsao Date

Abstract

We report the case of a patient with anaplastic astrocytoma whose 2 recurrent lesions showed different imaging responses from one another after bevacizumab treatment. Histologic and genetic features of this patient are also described. A 31-year-old patient with left temporal anaplastic astrocytoma had surgery, local radiotherapy, and chemotherapy. Recurrent lesions appeared in the cerebellar vermis and left cerebellar hemisphere, and the patient was started on biweekly bevacizumab. Subsequently, the 2 enhanced lesions showed different response patterns on magnetic resonance imaging. Although the lesion in the cerebellar vermis showed an enlargement of enhancing mass, the lesion in the left cerebellar hemisphere showed disappearance of enhancement. We resected the cerebellar vermis lesion and performed biopsy on the cerebellar hemisphere lesion. The specimens were investigated. Both recurrent lesions showed higher Ki-67 labeling indices and pericyte proliferation, and less angiogenesis compared with the initial specimen. Transmission electron microscopy showed a reduction in the distance between the endothelial cells and tumor cells in both recurrent lesions, compared with the initial lesion. However, the tight junctions in the ...Continue Reading

References

Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Sep 24, 2005·Nature·Sara M Weis, David A Cheresh
Oct 4, 2006·The Journal of Clinical Investigation·Michael R MancusoDonald M McDonald
Nov 11, 2008·Nature·Joshua I GreenbergDavid A Cheresh
Jun 3, 2009·The Oncologist·Andrew S ChiTracy T Batchelor
Aug 12, 2009·Neurobiology of Disease·N Joan AbbottDavid J Begley
Apr 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael DeLayManish K Aghi
Feb 21, 2014·The New England Journal of Medicine·Mark R GilbertMinesh P Mehta
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
Apr 8, 2014·Translational Oncology·Joji IshidaIsao Date
Jun 20, 2014·Nature Communications·Stacey WatkinsHarald Sontheimer
Jan 8, 2015·Frontiers in Cellular Neuroscience·Luiz Gustavo DuboisVivaldo Moura-Neto
Jul 1, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas SandmannCarlos Bais
May 14, 2016·Neurologia Medico-chirurgica·Tomotsugu IchikawaIsao Date

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