Comparative histopathological study of sporotrichosis and American tegumentary leishmaniasis in dogs from Rio de Janeiro

Journal of Comparative Pathology
Luisa H M MirandaT M Pacheco Schubach

Abstract

Pyogranulomatous lesions from 80 dogs with sporotrichosis and 26 dogs with American tegumentary leishmaniasis (ATL) were compared microscopically in order to identify features that would support the diagnostic suspicion and direct the subsequent search for the aetiological agent of either infection. Odds ratios and their respective 95% confidence intervals were calculated in order to evaluate the impact of the microscopical findings on the diagnosis of either disease. Lesions with well-formed granulomata were 14 times more likely to be due to sporotrichosis than ATL. Marked neutrophil infiltration into granulomata was 12.26 times more likely to be associated with sporotrichosis when compared with lesions having mild neutrophilic infiltration. Absence of lymphocytes and macrophages in the peripheral infiltrate was associated with a 9.71 and 4.93 higher chance, respectively, of being sporotrichosis rather than ATL compared with lesions where these cells were present. Lesions with a perivascular, perifollicular and interstitial peripheral inflammatory infiltrate were 5.48 times more likely to be due to sporotrichosis than ATL when compared with lesions with a diffuse peripheral infiltrate. Histopathological analysis may therefore ...Continue Reading

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Citations

Apr 30, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Luisa H M MirandaTânia M P Schubach
Oct 7, 2011·Clinical Microbiology Reviews·Mônica Bastos de Lima BarrosArmando Oliveira Schubach
May 16, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Isabele Barbieri dos SantosTânia Maria Pacheco Schubach
Feb 12, 2014·Journal of Clinical Imaging Science·Jones Raja Devathambi, Nalini Aswath

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