PMID: 43290Dec 1, 1979

Comparative immunogenicity of group 6 pneumococcal type 6A(6) and type 6B(26) capsular polysaccharides

Infection and Immunity
J B RobbinsJ Henrichsen

Abstract

The comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6A(6) and type 6B(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6A (U.S. designation, type 6) or 50 mug each of type 6A and type 6B (U.S. designation, type 26) polysaccharides. Both group 6 polysaccharides were linear copolymers composed of 1 mol each of d-galactose, d-glucose, l-rhamnose, and d-ribitol phosphate. They differed only in that type 6A had a rhammopyranosyl-(1 --> 3)-d-ribitol bond and the type 6B had a rhamnopyranosyl-(1 --> 4)-d-ribitol bond. Quantitative precipitation and absorption analyses with rabbit hyperimmune antisera induced by simultaneous injection with type 6A and type 6B organisms revealed extensive cross-reactions between the two group 6 polysaccharides. There was less, although still quite extensive, cross-reactivity between the two group 6 polysaccharides examined with antisera from rabbits injected with only one of the group 6 pneumococci. In a radioimmunoassay, using (14)C internally labeled type 6A or type 6B polysaccharide antigens, there was no difference in the...Continue Reading

References

Jan 1, 1986·Scandinavian Journal of Infectious Diseases·L A BurmanJ Henrichsen
Jul 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J C Butler
Jul 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·R Austrian
May 9, 2000·Clinical and Diagnostic Laboratory Immunology·A SoininenH Käyhty
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew P SteenhoffKarin L McGowan
Jun 15, 2000·Pharmacotherapy·L M DickersonP J Carek
Oct 27, 2009·Chembiochem : a European Journal of Chemical Biology·Archana R ParameswarAlexei V Demchenko
Jan 3, 2014·Organic & Biomolecular Chemistry·Shaheen K MulaniKwok-Kong Tony Mong
Apr 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·F K Pedersen, J Henrichsen
Oct 1, 1983·European Journal of Clinical Microbiology·J H BraconierH Odeberg
Sep 30, 2003·Scandinavian Journal of Infectious Diseases·Jonas HedlundGöran Kronvall

Related Concepts

Precipitin Tests
Variolation
Haemophilus influenzae
Immune Sera
Phosphate Measurement
Cross Reactions
Phosphoglycerate Dehydrogenase Activity
Galactose
Polysaccharides, Bacterial
Bacterial Vaccines

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