Comparative immunogenicity of hepatitis B vaccine with different dosages and schedules in healthy young adults in China

Vaccine
Zhen-Zi WangHui Zhuang

Abstract

To compare immunogenicity of hepatitis B vaccine between the standard 3-dose (20 μg) and 2-dose with higher-dosage (60 μg) regimens in healthy young adults and evaluate the safety profile. A randomized, parallel-group clinical trial was conducted among healthy young adults aged 18-25 years. Subjects were randomly assigned to three groups. One group was administered hepatitis B vaccine with the standard regimen of 0-1-6 month (20 μg) and other groups were immunized with regimens of 0-1 or 0-2 month (60 μg) respectively. Serum samples were collected at 1 month after a series vaccination and 12 months after the first-dose inoculation for anti-HBs antibody measurement with a Chemiluminescent Microparticle ImmunoAssay (CMIA). The seroprotection rates in 20 μg (0-1-6 month), 60 μg (0-1 month) and 60 μg (0-2 month) groups were 100, 93.64 and 99.19% at month 7/2/3, and 100, 96.04 and 95.90% at month 12, respectively. There were no significant differences among three vaccine groups (p>0.05). The geometric mean concentration (GMC) of anti-HBs was significantly higher in 20 μg (0-1-6 month) group than that in 60 μg (0-1 month) group at month 7/2 (1847.99 vs. 839.27 mIU/ml, p=0.004), but was similar to that in 60μg (0-2 month) group at mon...Continue Reading

References

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