Comparative immunological effect of anticoagulant and antioxidant therapy in the prevention of abortion in mice

American Journal of Reproductive Immunology : AJRI
Gisela JunovichGabriela Gutierrez

Abstract

Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Pregnant females from CBA/J × DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.

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Citations

May 8, 2013·American Journal of Reproductive Immunology : AJRI·Gisela JunovichGabriela Gutierrez
Sep 8, 2011·Expert Review of Clinical Immunology·Udo R MarkertJustine S Fitzgerald

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