PMID: 7539247Jan 1, 1995Paper

Comparative immunoreactivity of the eosinophil constituents MBP and ECP in different types of urticaria

Archives of Dermatological Research
N HaasB M Czarnetzki

Abstract

In order to elucidate the role of eosinophil constituents in urticaria, we investigated major basic protein expression immunohistologically in comparison with that of eosinophilic cationic protein and the low-affinity IgE receptor in lesional and uninvolved skin of different types of urticaria. Eosinophil activation was studied with the markers EG1 and EG2. Different eosinophil constituents were found in all urticarial lesions except those of urticaria pigmentosa. MBP staining tended to be distributed diffusely throughout the tissue, whereas EG1 and EG2 antibodies were located at or close to individual cells. Staining with the low affinity IgE receptor antibody was rare. In uninvolved skin, major basic protein and particularly eosinophilic cationic protein reactivity was found in chronic recurrent urticaria, delayed pressure urticaria and, to a minor degree, in cholinergic urticaria. No correlation was found between antibody reactivity and eosinophil counts. Reactivity with either of the eosinophil constituents is thus a better marker for eosinophil involvement than routine H&E staining of the cells. The demonstration of eosinophil constituents in non-lesional skin of some urticaria patients suggests generalized eosinophil acti...Continue Reading

References

May 1, 1991·The Journal of Allergy and Clinical Immunology·B ZweimanG J Gleich
Jan 1, 1990·International Archives of Allergy and Applied Immunology·A HammarlundL Enerbäck
Jul 1, 1989·Journal of the American Academy of Dermatology·K M LeifermanR K Winkelmann
Oct 1, 1989·The Journal of Investigative Dermatology·B M CzarnetzkiC Sorg
Jan 1, 1989·International Archives of Allergy and Applied Immunology·B M Czarnetzki, M Csatò
Feb 1, 1985·Journal of the American Academy of Dermatology·B M CzarnetzkiE B Bröcker
Jan 1, 1988·Journal of Clinical Immunology·R F Lemanske, M Kaliner
Sep 1, 1986·Journal of the American Academy of Dermatology·K M LeifermanG J Gleich
Mar 1, 1987·Journal of the American Academy of Dermatology·M S PetersG J Gleich
Jan 1, 1985·International Archives of Allergy and Applied Immunology·C J SpryJ Barkans
Jul 1, 1983·The Journal of Investigative Dermatology·M S PetersG J Gleich
Jun 1, 1983·The Journal of Experimental Medicine·M C O'DonnellL L Thomas
Jan 15, 1981·The New England Journal of Medicine·A E Butterworth, J R David
Mar 1, 1981·The Journal of Clinical Investigation·D L WassomG J Gleich
Aug 1, 1993·The British Journal of Dermatology·J GrabbeB M Czarnetzki
Jun 1, 1994·The British Journal of Dermatology·B HermesB M Czarnetzki

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Citations

Dec 4, 2003·Mund-, Kiefer- und Gesichtschirurgie : MKG·A BüchterJ Kleinheinz
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T Zuberbier, B M Henz
May 29, 1998·The British Journal of Dermatology·E ToppeB M Henz
Jul 18, 2002·International Journal of Dermatology·Alessandra FrezzoliniGino A Vena
May 9, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kai-Lin ChangBor-Luen Chiang
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·N HaasB M Henz
Nov 26, 2009·Dermatologic Therapy·Nicoletta CassanoGino Antonio Vena
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·B HermesB M Henz
Mar 18, 2019·International Archives of Allergy and Immunology·Eric Tyrell OliverSarbjit Singh Saini

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