Comparative impact of paraclinical studies in establishing the diagnosis of multiple sclerosis.

Electroencephalography and Clinical Neurophysiology
R L GilmoreE Norvell

Abstract

We prospectively examined 58 patients with suspected or confirmed multiple sclerosis (MS) to evaluate the impact of paraclinical studies (evoked potentials (EPs) and magnetic resonance imaging (MRI] in the diagnostic evaluation of these patients. All patients had cranial MRI studies, brain-stem auditory (BAEP), visual (VEP), posterior tibial (PTN-SSEP) and median somatosensory (MN-SSEP) EPs. Patients were categorized according to criteria of Poser et al. initially without knowledge of paraclinical studies. On the basis of clinical history, neurological examination and CSF chemical analysis, there were 18 (31%) clinically definite (CD). 10 (17%) laboratory supported definite (LSD), 13 (22%) clinically probable (CP) MS cases; 17 (29%) cases could not be classified. By providing electrophysiological and/or anatomical evidence for a 'second lesion,' paraclinical studies permitted 25 patients to move from one diagnostic category to another, reflecting an increased certitude of the diagnosis. Twelve moved to CDMS by either MRI or one EP study. Four moved to CDMS on the basis of MRI only, and four moved to CDMS by VEP only. Five moved from an unclassified status to either LSDMS or CPMS by PTN-SSEP (2), by PTN-SSEP or MRI (1), by MRI o...Continue Reading

References

Nov 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·R L GilmoreR G McAllister
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Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
May 1, 1952·The American Journal of Medicine·R D ADAMS, C S KUBIK

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Citations

Oct 24, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J C Aminoff, D S Goodin

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