Comparative in situ study of the intestinal absorption of aluminum, manganese, nickel, and lead in rats

Biological Trace Element Research
Nathalie ArnichDaniel Burnel

Abstract

This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues after 1 h. The perfused metal solutions were at concentrations likely to occur during oral intoxication. It was found that aluminum (48 and 64 mM), even as a citrate complex, crossed the brush border with difficulty (0.4% of the perfused amount); about 60% of this was retained in the intestine and the remainder was found in target tissues (about 36%). Conversely, lead (4.8-48 microM) penetrated the intestine more easily (about 35% of the perfused amount), was slightly retained (about 12% of the input), and was soon found in the tissues (about 58% of the input) and to a lesser degree in circulation (about 29%). Within the same concentration range, nickel and manganese showed certain similarities, such as a reduced crossing of the brush border proportional to the increase in the concentration perfused (0.17-9.5 mM). There was similar intestinal retention and absorption (about 80% and 20% of the input, respectively). M...Continue Reading

Citations

Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Roberto GwiazdaDonald Smith
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Apr 21, 2012·Pakistan Journal of Biological Sciences : PJBS·Mohammad Hossein AarabiMehdi Mirhashemi
Jan 15, 2016·Morphologie : Bulletin De L'Association Des Anatomistes·D ChappardL Hubert
Apr 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert A YokelRebecca L Florence

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