Comparative in vitro activities of the novel antibacterial finafloxacin against selected Gram-positive and Gram-negative bacteria tested in Mueller-Hinton broth and synthetic urine

Antimicrobial Agents and Chemotherapy
A DalhoffS Schubert

Abstract

Kill kinetics and MICs of finafloxacin and ciprofloxacin against 34 strains with defined resistance mechanisms grown in cation-adjusted Mueller-Hinton broth (CAMHB) at pH values of 7.2 and 5.8 and in synthetic urine at pH 5.8 were determined. In general, finafloxacin gained activity at low pH values in CAMHB and remained almost unchanged in artificial urine. Ciprofloxacin MICs increased and bactericidal activity decreased strain dependently in acidic CAMHB and particularly in artificial urine.

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Related Concepts

Gram-Positive Bacteria
Urine
Ciprofloxacin
Gram-Negative Bacteria
Cations
Acids
Ciprinol
Urine - SpecimenType
Anti-Bacterial Agents
Finafloxacin

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