Comparative in vitro activity of lomefloxacin, a new difluoroquinolone

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
A M Clarke, S J Zemcov

Abstract

The in vitro activity of lomefloxacin, a new difluoroquinolone, was compared with that of norfloxacin, ciprofloxacin, gentamicin and ceftazidime against a total of 577 recent clinical isolates. MICs were determined by a standard agar dilution procedure, and two inocula (10(4) and 10(6) CFU) were used throughout. Lomefloxacin inhibited most species of the Enterobacteriaceae, Staphylococcus aureus (including methicillin-resistant strains) and Haemophilus influenzae at less than or equal to 1 mg/l. Pseudomonas aeruginosa (MIC 90, 4 mg/l) was somewhat more resistant, and Pseudomonas maltophilia (MIC 90, 16 mg/l) and the Bacteroides fragilis group (MIC 90, 32 mg/l) were considerably more resistant. Overall, lomefloxacin was as active as norfloxacin, but was two- to eightfold less active than ciprofloxacin against most species tested.

References

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Citations

Sep 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E A BryceA M Clarke
Dec 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E DerlotP Courvalin
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·H M WexlerS M Finegold
Nov 1, 1993·Antimicrobial Agents and Chemotherapy·H M WexlerS M Finegold
Apr 6, 1992·The American Journal of Medicine·K H Mayer, J A Ellal
Nov 1, 1992·The Journal of International Medical Research·J Guibert, M H Capron
Sep 1, 1996·Antimicrobial Agents and Chemotherapy·H M WexlerS M Finegold

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