Comparative in-vitro activity of penicillin alone and combined with gentamicin against clinical isolates of Streptococcus pneumoniae with decreased susceptibility to penicillin

International Journal of Antimicrobial Agents
L AnadiotisA M Sefton

Abstract

The worldwide emergence of Streptococcus pneumoniae with decreased susceptibility to penicillin has led to the suggestion that drug combinations might be used. The aim of this study was to determine possible synergy using a combination of penicillin with sub-inhibitory doses of gentamicin against 26 clinical isolates of S. pneumoniae with decreased susceptibility to penicillin, using half-chequerboards and killing curves. Synergy was demonstrated for ten of the 26 isolates with the combination of penicillin with gentamicin at 1 mg/l and for 22 isolates with penicillin and gentamicin at 2 mg/l. Killing curves on three isolates showed synergy and confirmed the chequerboard results. Further synergy studies using penicillin or cefotaxime/ceftriaxone, plus low dose gentamicin against penicillin-resistant pneumococci are indicated.

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Citations

Apr 18, 2012·New Zealand Veterinary Journal·C L HerdanF E T Pauwels
Aug 13, 2009·The Journal of Infectious Diseases·Gary L DarmstadtUNKNOWN Bangladesh Projahnmo-2 (Mirzapur) Study Group
Feb 12, 2004·The Pediatric Infectious Disease Journal·Margaret Choi, Timothy Lloyd Mailman
Jan 11, 2007·Antimicrobial Agents and Chemotherapy·Judy N ChinPaul B Savage
Jan 29, 2014·The Journal of Antimicrobial Chemotherapy·Lindley A BarbeeMatthew R Golden
Feb 24, 2015·International Journal of Antimicrobial Agents·Torgny SunnerhagenMagnus Rasmussen
Jul 25, 2003·Expert Opinion on Pharmacotherapy·Trevor DukeDavid G Fuller

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