PMID: 8955735Oct 1, 1996Paper

Comparative in vitro activity of piperacillin/tazobactam against gram-negative bacilli

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
L D Liebowitz, K P Klugman

Abstract

To describe the in vitro activity of piperacillin/tazobactam against clinical isolates of Gram-negative bacteria, compared with other antibacterial agents. Survey of susceptibility of clinical isolates of Gram-negative bacilli. Academic hospitals of the University isolates of the Witwatersrand teaching complex. BACTERIAL STRAINS: 180 selected clinical isolates of Gram-negative bacilli. Minimum inhibitory concentrations (MICs) determined by agar dilution using techniques according to the recommendations of the National Committee for Clinical Laboratory Standards. Ciprofloxacin, biapenerm, imipenem, cefepime and cefpirome were all highly active against most of the Enterobacteriaceae. All the ampicillin-resistant strains of Enterobacteriaceae were susceptible to piperacillin/tazobactam, MIC90 values being 4/4 mg/l for Klebsiella and Proteus/Providencia spp., 8/4 mg/l for Citrobacter and Serratia spp., and 16/4 mg/l for Escherichia coli. All the agents, with the exception of ampicillin (MIC90 4 mg/l) and chloramphenicol (MIC90 4 mg/l), were highly active against the Haemophilus influenzae isolates tested. All Bacteroides fragilis strains were susceptible to piperacillin/tazobactam (MIC90 8/4 mg/l), as well as to co-amoxiclav (MIC90...Continue Reading

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.