Abstract
Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.
References
Jun 28, 2000·Nucleic Acids Research·R M BroshV A Bohr
Sep 29, 2004·Current Opinion in Microbiology·Fiona M Walsh, Sebastian G B Amyes
Mar 19, 2008·Clinical Orthopaedics and Related Research·Jason H CalhounM M Manring
Jul 29, 2009·Antimicrobial Agents and Chemotherapy·Rekha G PanchalSina Bavari
Mar 2, 2010·Bioorganic & Medicinal Chemistry·Timothy J OppermanTerry L Bowlin
Citations
Nov 15, 2012·The Journal of Antibiotics·Rekha G PanchalSina Bavari
Dec 17, 2011·Nature Chemical Biology·Henry H Lee, James J Collins
Jan 25, 2012·Antimicrobial Agents and Chemotherapy·Mohammad D MansouriRabih O Darouiche
Mar 1, 2012·Organic and Medicinal Chemistry Letters·Vagicherla Kameshwara RaoAnil Kumar
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wei ZhuEric Oldfield
Jan 13, 2015·Journal of Medicinal Chemistry·Wei ZhuEric Oldfield
Mar 12, 2015·Journal of Medicinal Chemistry·Angie M JarradMatthew A Cooper
Feb 21, 2013·Chemical Biology & Drug Design·Steffen LindertJ Andrew McCammon
Jul 26, 2015·Bioorganic & Medicinal Chemistry·Son T NguyenTimothy J Opperman
Feb 19, 2015·The Journal of Antimicrobial Chemotherapy·Yvan CasparMax Maurin
Dec 3, 2014·European Journal of Medicinal Chemistry·Ivana StolićMiroslav Bajić
Aug 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Syahrul ImranSaima Tauseef
Sep 19, 2014·Perspectives in Medicinal Chemistry·Richard J Fair, Yitzhak Tor
Sep 14, 2016·Antimicrobial Agents and Chemotherapy·Timothy J OppermanEric C Long
Sep 29, 2020·Archiv der Pharmazie·Tingting MengBo Zhang
Oct 7, 2011·Expert Review of Anti-infective Therapy·Matteo BassettiDaniele Roberto Giacobbe
Jul 4, 2020·European Journal of Medicinal Chemistry·Sergii DemchenkoAnatolii Demchenko
Jun 5, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Sugandha SinghalLeena Khanna
Aug 28, 2021·Antibiotics·Muni Kumar MahadariStephen G Pyne