Abstract
The in-vitro activity of AM-1155, a 6-fluoro-8-methoxy quinolone, was compared with those of temafloxacin, sparfloxacin, tosufloxacin, ciprofloxacin, ofloxacin and cefmetazole, a cephamycin, against a variety of anaerobic bacteria. Although AM-1155 demonstrated only modest activity against the Bacteroides fragilis group and Prevotella bivia (MIC90s > or =3.13 mg/mL), 76% of the B. fragilis strains tested were inhibited at AM-1155 concentrations of 0.78 mg/L. AM-1155 was highly active against Prevotella intermedia, Porphyromonas gingivalis, Fusobacterium spp., Clostridium perfringens and Mobiluncus spp. (MIC90s < or =0.39 mg/L). An in-vivo study using a mixed infection with AM-1155- and tosufloxacin-susceptible B. fragilis and Escherichia coli strains in rat granuloma pouch was performed. AM-1155 was effective against both organisms whereas tosufloxacin was effective only against E. coli. These results correlated well to the higher pouch levels of AM-1155 than those of tosufloxacin. Clostridium difficile overgrowth was found in the caecum of mice treated with ampicillin both 1 and 7 days after 5 days dosing, but not in AM-1155-treated mice. These results suggest that the clinical efficacy of AM-1155 against infections involving ...Continue Reading
Citations
Apr 23, 1999·Diagnostic Microbiology and Infectious Disease·R N JonesM A Pfaller
Apr 23, 1999·Diagnostic Microbiology and Infectious Disease·J Dubois, C St-Pierre
Dec 19, 2000·International Journal of Antimicrobial Agents·E HuczkoJ Fung-Tomc
Oct 27, 2006·Antimicrobial Agents and Chemotherapy·Kaori TanakaKunitomo Watanabe
Apr 20, 2000·Pharmacotherapy·K E PickerillJ J Schentag
Feb 24, 2001·Pharmacotherapy·D N Fish, D S North
Jul 5, 2005·Expert Opinion on Investigational Drugs·A Dalhoff
Nov 4, 2000·Expert Opinion on Investigational Drugs·J M Blondeau
Feb 20, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Ronald N. JonesMichael A. Pfaller
Jan 1, 2012·Ophthalmology and Eye Diseases·Clyde Schultz
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·L M EdnieP C Appelbaum
Oct 3, 1999·Antimicrobial Agents and Chemotherapy·G A PankuchP C Appelbaum
Oct 30, 1999·Antimicrobial Agents and Chemotherapy·R SchaumannA C Rodloff
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L DubreuilL Calvet