Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products for intravenous administration.

BMC Clinical Pharmacology
Edelberto SilvaAndrés de la Torre

Abstract

The antimicrobial resistance is a global problem, probably due to the indiscriminate and irrational use of antibiotics, prescriptions for incorrect medicines or incorrect determinations of dose, route and/or duration. Another consideration is the uncertainty of patients receiving antibiotics about whether the quality of a generic medicine is equal to, greater than or less than its equivalent brand-name drug. The antibiotics behaviors must be evaluated in vitro and in vivo in order to confirm their suitability for therapeutic use. The antimicrobial activities of Meropenem and Piperacillin/Tazobactam were studied by microbiological assays to determine their potencies (content), minimal inhibitory concentrations (MICs), critical concentrations and capacity to produce spontaneous drug-resistant mutants. With respect to potency (content) all the products fulfill USP requirements, so they should all be considered pharmaceutical equivalents. The MIC values of the samples evaluated (trade marks and generics) were the same for each strain tested, indicating that all products behaved similarly. The critical concentration values were very similar for all samples, and the ratios between the critical concentration of the standard and those ...Continue Reading

References

Mar 31, 2005·Journal of Pharmaceutical and Biomedical Analysis·Andreas S L MendezElfrides E S Schapoval

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Citations

May 30, 2013·Journal of Veterinary Pharmacology and Therapeutics·P-L Toutain, A Bousquet-Melou
Nov 23, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre TattevinRémy Gauzit
Jan 16, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Primadi AviantoChristopher Paul Alderman
Apr 16, 2013·Analytical Chemistry·Jing DaiJong Wook Hong

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Methods Mentioned

BETA
ELISA

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