Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments

Journal of Biomedical Materials Research. Part a
V BorsariRoberto Giardino

Abstract

Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 +/- 8 microm and 53 +/- 18 microm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 +/- 7 microm and 36 +/- 3 microm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen-deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push-out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 (p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA-coated surfaces (p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA-coated surfaces in trabecular bone (p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed (p < 0.05). Data showed that high roughness and Ti and HA-coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone.

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Citations

Apr 9, 2011·Journal of Materials Science. Materials in Medicine·Rahul BholaCatherine E Krull
May 23, 2013·Journal of Materials Science. Materials in Medicine·Yang LiZhen-An Zhu
Nov 6, 2009·Journal of the Royal Society, Interface·René BeutnerDieter Scharnweber
Apr 29, 2014·Journal of Materials Science. Materials in Medicine·L M AtaydeA C Maurício
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Nov 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Teng LongZhen-An Zhu
Nov 25, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ling RenKe Yang
Feb 22, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Petr HarcubaMiloš Janeček
Jan 1, 2012·Journal of Functional Biomaterials·Bedilu A AlloAmin S Rizkalla
Dec 22, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Stephan FroschGottfried Buchhorn

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