Comparative inner ear transcriptome analysis between the Rickett's big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)

BMC Genomics
Dong DongShuYi Zhang

Abstract

Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett's big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as 'cochlea morphogenesis', 'inner ear morphogenesis' and 'sensory perception of sound', which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits.

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Citations

Sep 30, 2017·MSphere·Diana L GerrardSeth Frietze
Apr 19, 2019·Scientific Reports·Diana D Moreno-SantillánJorge Ortega
Mar 15, 2020·Molecular Biology and Evolution·Michael R McGowenAnd Stephen J Rossiter
May 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·John A HawkinsSara L Sawyer

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Datasets Mentioned

BETA
SRR837386
SRR837385

Methods Mentioned

BETA
PCR
RNA-Seq

Software Mentioned

PAML
CODEML
BLASTX
Trinity
Illumina Genome Analyzer
house
CD
BLAST
Mafft
EBSeq

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

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