Comparative inotropic effects of local anesthetics in isolated cat papillary muscles

Journal of Anesthesia
O KemmotsuT Yamamura

Abstract

The direct inotropic action of seven local anesthetics: procaine, mapivacaine, lidocaine, tetracaine, chloroprocaine, bupivacaine and etidocaine were compared in isolated cat papillary muscles. All of the local anesthetics produced a dose-related depression of maximal velocity of shortening (Vmax), maximal developed force (Fm) and maximal dF/dt. The more potent local anesthetics such as bupivacaine and etidocaine depressed myocardial contractility at significantly lower concentrations than the less potent local anesthetics such as lidocaine and mepivacaine. Depression of Vmax by bupivacaine or etidocaine was three times greater than that by lidocaine and ten times greater than that by procaine. At the same concentration (10(-4) M), direct myocardial depression was demonstrated in the following order of severity: etidocaine >/= bupivacaine > tetracaine > chloroprocaine >/= lidocaine > mepivacaine > procaine.

References

Jul 1, 1986·British Journal of Anaesthesia·S Reiz, S Nath
Nov 1, 1985·Anesthesia and Analgesia·M A RosenM Koike
Jan 1, 1970·The American Journal of Cardiology·K M RosenA N Damato
Jan 1, 1984·Anesthesiology·G F Marx
Sep 1, 1963·Anesthesiology·D M STEWARTE F WOODS

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