PMID: 8949709Aug 1, 1996Paper

Comparative intraocular penetration of topical and injected cefuroxime

The British Journal of Ophthalmology
C D JenkinsR J Buckley

Abstract

The choice of a prophylactic antibiotic for cataract surgery is dependent on its antibacterial activity and tissue penetration. The influence of the route and timing of administration of cefuroxime on its intraocular concentrations was examined. 120 patients were recruited before cataract surgery into a prospective trial to compare the anterior chamber concentration of cefuroxime at a fixed time after administration by three routes. In a further 110 patients, the interval before sampling was varied in order to permit an examination of the kinetics of penetration. In another 10 patients, cefuroxime was given topically at the completion of surgery to assess the effect of a corneal wound on aqueous penetration. Cefuroxime concentrations were measured by high performance liquid chromatography on 0.2 ml samples of aqueous aspirated from the anterior chamber. Mean aqueous concentrations of cefuroxime for each group were compared using Student's t test. After 25 mg cefuroxime, mean aqueous concentrations increased in the order forniceal (< 0.1 microgram/ml) < topical (0.18 microgram/ml) < subconjunctival (2.31 microgram/ml) when sampled 12-24 minutes after administration. Aqueous concentrations of cefuroxime reached a peak between 80 ...Continue Reading

References

Jan 1, 1977·Antimicrobial Agents and Chemotherapy·W L WangE Dean
Mar 1, 1976·American Journal of Ophthalmology·D E OakleyP P Ellis
Dec 14, 1990·Pharmaceutisch Weekblad. Scientific Edition·T B Vree, Y A Hekster
Jun 1, 1987·The British Journal of Ophthalmology·D B Clements, V Tailor
Apr 1, 1986·Ophthalmology·W T DriebeW W Culbertson
Apr 1, 1986·Ophthalmic Surgery·L G WohlB D Galman
May 1, 1983·Survey of Ophthalmology·M B Starr
Apr 1, 1980·American Journal of Ophthalmology·J H Saunders, S D McPherson
Sep 1, 1980·American Journal of Ophthalmology·J L Axelrod, R S Kochman
Aug 1, 1982·Ophthalmology·C A PuliafitoC S Foster

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Citations

May 4, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kazuki Matsuura
Feb 16, 2010·Journal of Cataract and Refractive Surgery·David LockingtonDavid Yorston
Nov 22, 2020·Eye·James E NeffendorfTom H Williamson

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