PMID: 15218709Jun 29, 2004Paper

Comparative investigation of the desensitizing efficacy of a new dentifrice containing 5.5% potassium citrate: an eight-week clinical study

The Journal of Clinical Dentistry
Deyu HuW DeVizio

Abstract

This double-blind clinical study was designed to investigate the relative effectiveness of a new desensitizing test dentifrice containing 5.5% potassium citrate, 1.14% sodium monofluorophosphate (MFP) and 10% high-cleaning silica (HCS) in a silica base for reducing dentinal hypersensitivity over an eight-week period, to that of a commercially available desensitizing positive control dentifrice containing 3.75% potassium chloride, 0.32% sodium fluoride and 0.3% triclosan in a silica base. A total of 80 subjects were entered into the study, and stratified into two balanced groups according to their baseline mean thermal (air blast) and baseline mean tactile (Yeaple Probe) sensitivity scores. The two groups were randomly assigned to use either the test dentifrice containing potassium citrate/MFP/HCS, or the positive control dentifrice containing potassium chloride/sodium fluoride/triclosan. The two groups were well balanced with regard to their mean baseline thermal and tactile sensitivity scores, sex and age. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice and a commercially available soft-bristled toothbrush. Dentinal hypersensitivity examinations, whi...Continue Reading

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