Comparative mechanism based study on disinfectants against multidrug-resistant Acinetobacter baumannii

Journal of Cellular Biochemistry
Deepika BiswasVishvanath Tiwari

Abstract

Acinetobacter baumannii has emerged as a hospital-acquired pathogen and has spread in the hospital settings, leading to enhanced nosocomial outbreaks associated with high death rates. Therefore, the aim of the current study is to determine the effective concentration of disinfectants like sodium hypochlorite, hydrogen peroxide, and chlorine dioxide, against multidrug-resistant (MDR) strains of A. baumannii. In this study, we have investigated the effect of disinfectants on different MDR strains i.e. RS307, RS6694, RS7434, RS10953, RS122, and sensitive strain ATCC-19606 of A. baumannii, via differential growth curves analysis, disc diffusion assay, estimation of reactive oxygen species (ROS), lipid peroxidation, and protein carbonylation. All the results collectively showed that 1% sodium hypochlorite (P value < 0.0027), 2.5% hydrogen peroxide (P value = 0.0032), and 10 mM (P value = 0.017) chlorine dioxide significantly inhibit the growth of MDR strains of A. baumannii. A significant increase in the ROS generations, altered lipid peroxidation, and a decrease in protein carbonylation was also observed after treatment with disinfectants, which confirmed its ROS-dependent damage mechanism. These disinfectants also enhance the memb...Continue Reading

References

Mar 1, 1979·Applied and Environmental Microbiology·A K Camper, G A McFeters
Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Sep 20, 2002·Brazilian Dental Journal·Carlos EstrelaJesus D Pécora
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Daniele Del RioNicoletta Pellegrini
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George H TalbotUNKNOWN Antimicrobial Availability Task Force of the Infectious Diseases Society of America
May 15, 2007·The Journal of Hospital Infection·H WisplinghoffH Seifert
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Aug 12, 2009·Applied Microbiology and Biotechnology·Wen-Ru LiYi-Ben Chen
May 14, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M SengstockK S Kaye
May 28, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joel Fishbain, Anton Y Peleg
Jul 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronald N Jones
Aug 18, 2010·The Journal of Antimicrobial Chemotherapy·Michelle FinneganJean-Yves Maillard
Sep 29, 2011·Antimicrobial Agents and Chemotherapy·Rodrigo CayôLuis Martínez-Martínez
Apr 26, 2012·The Journal of Antimicrobial Chemotherapy·Ezra LinleyJean-Yves Maillard
May 23, 2012·Microbial Pathogenesis·Vishvanath TiwariRajeswari R Moganty
Jan 8, 2013·Nature Biotechnology·Mark P BrynildsenJames J Collins
Jul 25, 2013·Journal of Biomolecular Structure & Dynamics·Vishvanath Tiwari, Rajeswari R Moganty
Nov 14, 2013·PloS One·Zoltán NoszticziusJános Szegedi
Jan 7, 2015·Redox Biology·Edyta AugustyniakHelen R Griffiths
Apr 8, 2015·Journal of Bacteriology·Larry A GallagherColin Manoil
Jul 8, 2015·Frontiers in Microbiology·Vishvanath TiwariMonalisa Tiwari
Feb 26, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Monalisa TiwariVishvanath Tiwari
May 17, 2017·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Saifalarab A MohmmedJonathan C Knowles
Feb 8, 2018·The Journal of Antibiotics·Vishvanath TiwariDeepika Biswas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

© 2022 Meta ULC. All rights reserved