Comparative metabolism of gestagens and estrogens in the four lynx species, the Eurasian (Lynx lynx), the Iberian (L. pardinus), the Canada lynx (L. canadensis) and the bobcat (L. rufus)

General and Comparative Endocrinology
M DehnhardK Jewgenow

Abstract

With the increasing prevalence of faecal hormone metabolite analysis, it is important to develop a better understanding of the dynamics of faecal metabolite composition. The aim of this study was to compare the quantitative faecal gestagen and estrogen metabolite composition in the four lynx species: Eurasian lynx, Iberian lynx, Canada lynx and bobcats. Comparative HPLC immunograms were generated from faecal samples collected before, during, and after pregnancy from individual females of each lynx species. Gestagens and estrogens revealed three similar classes of immunoreactive faecal metabolites: (1) polar metabolites which were enzyme-hydrolysable and thus may be designated as conjugates, (2) non-hydrolysable polar metabolites, and (3) non-polar metabolites or free steroids. For both hormones, strong similarities in the HPLC immunograms across species suggests that steroid metabolism is relatively conserved among Lynx species. Gestagens were primarily excreted as polar conjugates or unknown metabolites, whereas estrogen metabolism revealed a huge proportion (approximately 50%) consisting of 17beta-estradiol and estrone. These results are consistent with patterns of steroid metabolism in other felid species. Only two minor spe...Continue Reading

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Sep 21, 2010·General and Comparative Endocrinology·Kerry V FansonJeffrey R Lucas

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Citations

Jul 26, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Kim CarnabyKatarina Jewgenow
Jul 1, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kerry V FansonJeffrey R Lucas
Sep 21, 2010·General and Comparative Endocrinology·Kerry V FansonJeffrey R Lucas
Sep 25, 2015·General and Comparative Endocrinology·Serena A BarnesLinda M Penfold
Aug 21, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Lina ZschockeltBeate C Braun
Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Shilpa N KaoreRaj Sharma
Aug 10, 2019·PloS One·Alexandre AzevedoKatarina Jewgenow
Aug 2, 2014·Zoo Biology·Javier YergaAntonio Rivas
Mar 11, 2020·Conservation Physiology·Katarina JewgenowMartin Dehnhard

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