Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques

Phytochemistry
Mohamed A FaragLudger A Wessjohann

Abstract

Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and possesses anticancer and antiviral activities. This species contains a plethora of phytochemicals including terpenoids, saponins, flavonoids, polyamines and polysaccharides. The full complement of bioactive compounds has yet to be elucidated, a step necessary in order to explain its medicinal use. There are over 30 species in the Glycyrrhiza genus world-wide, most of which have been little characterized in terms of phytochemical or pharmacological properties. Here, large scale multi-targeted metabolic profiling and fingerprinting techniques were utilized to help gain a broader insight into Glycyrrhiza species chemical composition. UV, MS and NMR spectra of extracted components were connected with NMR, MS, and multivariate analyses data from Glycyrrhiza glabra, Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza echinata. Major peaks in (1)H NMR and MS spectra contributing to the discrimination among species were assigned as those of glycyrrhizin, 4-hydroxyphenyl acetic acid, and glycosidic conjugates of liquiritigenin/isoliquiritigenin. Primary metabolites profiling using GC-MS reve...Continue Reading

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Citations

Sep 14, 2013·Natural Product Research·Dalia M RasheedMohamed A Farag
Dec 18, 2013·Journal of Pharmaceutical and Biomedical Analysis·Shuai JiMin Ye
Apr 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry· EerdunbayaerTsutomu Hatano
May 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verónica Rachel OlateGuillermo Schmeda-Hirschmann
Jul 25, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Yeon YuSeikwan Oh
Nov 27, 2015·Journal of Separation Science·Zhenhua zhuJin-ao Duan
Jan 24, 2016·BMC Complementary and Alternative Medicine·Jae-Chul JungYoung-Suk Jung
Mar 21, 2013·Journal of Pharmaceutical and Biomedical Analysis·Yanyan WangQinglin Zhang
Aug 1, 2014·Journal of Natural Products·Charlotte SimmlerGuido F Pauli
Jan 7, 2016·Frontiers in Microbiology·Olaf TycPaolina Garbeva
Nov 6, 2015·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Atsuko TadaHiroshi Akiyama
Sep 13, 2013·Journal of Food Science·Mohamed A Farag, Paul W Paré
Aug 6, 2015·Journal of Natural Products·Charlotte SimmlerGuido F Pauli
Feb 17, 2015·Journal of Advanced Research·Engy A Mahrous, Mohamed A Farag
Jan 13, 2015·Analytical and Bioanalytical Chemistry·Mohamed A FaragLudger A Wessjohann
Jun 18, 2014·Natural Product Research·Mohamed A FaragLudger A Wessjohann
May 24, 2016·Natural Product Research·Elvira E ShultsPetr G Gorovoy

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