Comparative metabolomic analysis reveals global cadmium stress response of Lactobacillus plantarum strains

Metallomics : Integrated Biometal Science
Qixiao ZhaiWei Chen

Abstract

Our previous work demonstrated the protective effects of Lactobacillus plantarum (L. plantarum) strains against cadmium (Cd) toxicity in vivo, and also indicated that the Cd tolerance of the strains played an important role in this protection. The goal of this study was to investigate the Cd resistance mechanism of L. plantarum by liquid chromatography-mass spectrometry (LC-MS) based metabolomic analysis, with a focus on the global Cd stress response. L. plantarum CCFM8610 (strongly resistant to Cd) and L. plantarum CCFM191 (sensitive to Cd) were selected as target strains, and their metabolomic profiles with and without Cd exposure were compared. The underlying mechanisms of the intra-species distinction between CCFM8610 and CCFM191 in terms of Cd tolerance can be attributed to the following aspects: (a) CCFM8610 possesses a higher intracellular content of osmolytes; (b) CCFM8610 can induce more effective biosynthesis of extracellular polymeric substance (EPS) to sequestrate Cd;

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Citations

Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Honglun YuanShouwen Chen
Sep 24, 2019·Frontiers in Molecular Biosciences·Elvina ParlindunganOliver A H Jones
Aug 2, 2019·Journal of Food Biochemistry·Chao Tang, Zhaoxin Lu
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fengyu GuoWeijun Chen

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Methods Mentioned

BETA
nuclear magnetic resonance
PCA
phosphotransferase
environmental stress

Software Mentioned

XCMS
SIMCA
P +
R
MBRole
Agilent MassHunter Qualitative

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