Comparative mobilization of lead by chelating agents

Toxicology
Z F Xu, M M Jones

Abstract

The relative abilities of approximately 20 chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the mouse. The acute LD50 for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i.p. injection with a 95% confidence interval of 87.1-210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver, kidney, spleen, bone and brain levels of lead was determined. The movement of lead from the liver to the bone was followed during the first 7 days post injection and was found to result in appreciable changes in the lead levels of these organs from day to day during this entire period. Of the compounds examined, the ones which were most effective in mobilizing lead under various conditions included meso-2,3-dimercaptosuccinic acid (DMSA), sodium 2,3-dimercaptopropane-1-sulfonate (DPMS), disodium calcium ethylene-diaminetetraacetate (Na2CaEDTA), trisodium zinc triethylenetetraminehexa-acetate, dicalcium ethylenediaminetetra(methylenephosphonate) (Ca2EDTPO) and diethyl dimercaptosuccinate (DEMSA) and 2,3-dimercapto-1-propanol (BAL).

References

Sep 1, 1976·The Journal of Pharmacy and Pharmacology·E FriedheimC H Wakker
Dec 1, 1977·Toxicology and Applied Pharmacology·L D Koller, J A Brauner
Nov 20, 1975·Archives of Toxicology·U Hofmann, G Segewitz
Jun 1, 1988·Toxicology Letters·P K SinghM M Jones
Sep 1, 1987·Medical Toxicology and Adverse Drug Experience·K Hruby, A Donner
Feb 1, 1971·Toxicology and Applied Pharmacology·P B Hammond
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·H V Aposhian
May 1, 1983·Bulletin of Environmental Contamination and Toxicology·S K TandonS Singh
Sep 15, 1984·Toxicology and Applied Pharmacology·C F Brownie, A L Aronson
Mar 15, 1984·Toxicology and Applied Pharmacology·T Twarog, M G Cherian
Feb 1, 1983·Bulletin of Environmental Contamination and Toxicology·T A Twarog, M G Cherian
Jan 1, 1980·Archives of Environmental Contamination and Toxicology·E M SorensenA Lindenbaum
Jul 1, 1962·British Journal of Industrial Medicine·J D WILLIAMSA W JUDD

❮ Previous
Next ❯

Citations

Oct 6, 1995·European Journal of Pharmacology·F Martinez-GarciaA Cremades
Apr 16, 1998·The Journal of Emergency Medicine·K A Graeme, C V Pollack
Jan 17, 2002·Neurotoxicology and Teratology·R E LaskyN K Laughlin
Jan 1, 1989·Journal of Toxicology and Environmental Health·P K SinghL M Atkins
Jan 1, 1991·Postgraduate Medical Journal·P S Thomas, C Ashton
Sep 1, 1992·Toxicology and Applied Pharmacology·D R Smith, A R Flegal
Jan 2, 2007·Neurotoxicology and Teratology·Stéphane A BeaudinBarbara J Strupp
Oct 27, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sally Bradberry, Allister Vale
Jan 1, 1995·Journal of Toxicology. Clinical Toxicology·D Jacobsen
Aug 28, 1998·Environmental Research·D SmithB J Strupp
Jan 6, 2000·Toxicology and Applied Pharmacology·J D CreminD R Smith
Oct 18, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alicia M BoltKoren K Mann
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ana I Sánchez-FructuosoAlberto Barrientos
Jan 1, 1991·Critical Reviews in Toxicology·M M Jones
May 1, 1996·Ultrastructural Pathology·V Vicente-OrtegaF Martínez-Díaz
Jul 29, 2010·Clinical Pharmacology and Therapeutics·M J Kosnett
Dec 2, 1991·The Medical Journal of Australia·F X ParnisR E Sage
Aug 2, 1993·European Journal of Pharmacology·F MartínezA Cremades

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.