PMID: 11931976Apr 5, 2002Paper

Comparative modeling of the latent form of a plant catechol oxidase using a molluskan hemocyanin structure

Journal of Inorganic Biochemistry
C GerdemannB Krebs

Abstract

The structure of the precursor form of catechol oxidase from sweet potatoes (Ipomoea batatas) has been modeled on the basis of the 3D structural data of mature catechol oxidase [Nat. Struct. Biol. 5 (1998) 1084] and of hemocyanin from giant octopus (Octopus dofleini) [J. Mol. Biol. 278 (1998) 855]. A C-terminal extension peptide is found in the cDNA sequence but not in the purified, mature form of catechol oxidase. Superimposition of the 3D structures of the native hemocyanin and catechol oxidase reveals a close relationship except for an additional C-terminal domain only found in the hemocyanin structure. As sequence alignment shows good homology this domain of the hemocyanin structure was used as a template to model the 3D structure of the C-terminal extension peptide of catechol oxidase. As hemocyanins show no or only weak catecholase activity due to this domain this indicates an inhibitory function of this extension peptide. Beside this possible shielding function for the precursor form, evidence for a function in copper-uptake also increases due to the location of three histidine residues in the model.

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Citations

Mar 27, 2004·Developmental and Comparative Immunology·Heinz Decker, Elmar Jaenicke
Dec 3, 2003·The International Journal of Biochemistry & Cell Biology·L G FenollJ Tudela
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·G Van RanstV Fievez
Feb 13, 2013·Journal of the Science of Food and Agriculture·Michael L Sullivan, Jamie L Foster
Mar 30, 2010·The FEBS Journal·Michael Fairhead, Linda Thöny-Meyer
Apr 13, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Sanchari DasguptaDebasis Das
Mar 5, 2014·Chemical Reviews·Edward I SolomonLi Tian
Jun 23, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Isabel BentoPeter F Lindley
Jun 24, 2006·Angewandte Chemie·Heinz DeckerFelix Tuczek
Feb 7, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Tonmoy ChakrabortyDebasis Das
May 1, 2019·Angewandte Chemie·Sarah M PrexlerMareike E Dirks-Hofmeister
Jan 19, 2010·Journal of Agricultural and Food Chemistry·Ifat ParveenAna Winters
Oct 3, 2008·Journal of Inorganic Biochemistry·William H Flurkey, Jennifer K Inlow
Dec 12, 2007·Journal of Agricultural and Food Chemistry·George E SchmitzRonald D Hatfield
Jan 13, 2005·Journal of the American Chemical Society·Armand W J W TepperGerard W Canters
Aug 18, 2005·Journal of Agricultural and Food Chemistry·Fernando Gandía-HerreroJosefa Escribano

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