Comparative morphologic and immunohistochemical investigation of spontaneously occurring thymomas in a colony of European hamsters

Veterinary Pathology
K BrandesW Hermanns

Abstract

This study documents the characteristics of a large series of spontaneously occurring thymomas in a laboratory colony of European hamsters (Cricetus cricetus). Thymomas are rare organotypic neoplasms originating from the thymic epithelial compartment. Because the hamster thymomas largely resembled their human counterparts, the recent World Health Organization (WHO) classification of human thymic epithelial tumors was used. Forty hamsters of both sexes aged 3-29 months were examined macroscopically and histologically. In 22 (55%) of the 40 animals, necropsy revealed enormous whitish masses in the anterior mediastinum, with a diameter ranging from 0.5 to 4.5 cm and a lobulated structure. The anatomy of the thymus region was normal in the remaining 18 hamsters. Histologically, the tumors presented as thymuslike organoid structures with areas of medullary and cortical differentiation and a predominance of lymphoid cells. A network of epithelial cells in the cortical areas, demonstrated immunohistochemically with a cross-reactive antibody against pancytokeratin, supported the diagnosis of thymoma. Cortical lymphocytes showed positive staining with cross-reacting antibodies against CD3 and terminal deoxynucleotidyl transferase, chara...Continue Reading

References

Dec 1, 1992·The American Journal of Surgical Pathology·T KirchnerH K Müller-Hermelink
Aug 1, 1988·Journal of Comparative Pathology·D C NaylorH J Ruefenacht
Jul 1, 1985·The Veterinary Clinics of North America. Small Animal Practice·M Aronsohn
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Marino, H K Müller-Hermelink
Mar 1, 1971·The Journal of Pathology·D FrancisJ J Kramer
Oct 1, 1965·The Journal of Pathology and Bacteriology·F N Ghadially, O Illman
Oct 1, 1995·The American Journal of Surgical Pathology·J K ChanM Y Pau
Mar 1, 1997·Archives of Histology and Cytology·H K Müller-HermelinkA Marx
Oct 10, 1997·The Journal of Small Animal Practice·M J Day
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C R ThomasP J Loehrer
Jul 6, 2000·The American Journal of Pathology·A ZettlA Marx
Sep 7, 2000·Current Opinion in Oncology·H K Müller-Hermelink, A Marx
Jul 27, 2001·Veterinary Pathology·J H SimmonsC L Besch-Williford

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
PCR
electrophoresis
electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
K M Walsh, J Poteracki
The Journal of Pathology and Bacteriology
F N Ghadially, O Illman
© 2022 Meta ULC. All rights reserved