Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels: impact of after treatment devices: oxidation catalyst and particulate filter

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
V AndréF Sichel

Abstract

Diesel exhausts are partly responsible for the deleterious effects on human health associated with urban pollution, including cardiovascular diseases, asthma, COPD, and possibly lung cancer. Particulate fraction has been incriminated and thus largely investigated for its genotoxic properties, based on exposure conditions that are, however, not relevant for human risk assessment. In this paper, original and more realistic protocols were used to investigate the hazards induced by exhausts emitted by the combustion of standard (DF0) vs. bio-diesel fuels (DF7 and DF30) and to assess the impact of exhaust treatment devices (DOC and DPF). Mutagenicity and genotoxicity were evaluated for (1) resuspended particles ("off line" exposure that takes into account the bioavailability of adsorbed chemicals) and for (2) the whole aerosols (particles+gas phase components) under continuous flow exposure ("on line" exposure). Native particles displayed mutagenic properties associated with nitroaromatic profiles (YG1041), whereas PAHs did not seem to be involved. After DOC treatment, the mutagenicity of particles was fully abolished. In contrast, the level of particle deposition was low under continuous flow exposure, and the observed mutagenicity...Continue Reading

References

Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Oct 3, 2002·The European Respiratory Journal·G D'AmatoM Cazzola
Dec 24, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeanine A HarriganJames R Olson
Mar 22, 2007·Archives of Toxicology·Jürgen BüngerThomas Brüning
Jun 9, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Michaela Aufderheide, Helga Gressmann
Jan 15, 2008·Journal of Epidemiology and Community Health·Ferran BallesterUNKNOWN Apheis network
May 13, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jean-Paul MorinFrédéric Dionnet
Jun 13, 2008·Environmental Science & Technology·Norbert V HeebAndreas Mayer
Mar 7, 2012·Journal of the National Cancer Institute·Michael D AttfieldDebra T Silverman
Mar 7, 2012·Journal of the National Cancer Institute·Debra T SilvermanMichael D Attfield
Jun 5, 2012·Critical Reviews in Toxicology·John F GamblePaolo Boffetta
Aug 9, 2012·Critical Reviews in Toxicology·Jürgen BüngerGötz A Westphal
Feb 13, 2013·Environmental and Molecular Mutagenesis·Michael M Iba, Robert J Caccavale
Sep 10, 2013·Journal of the Air & Waste Management Association·Shaohua HuAlberto Ayala

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Citations

Oct 31, 2015·Inhalation Toxicology·Esra MutluDavid M DeMarini
Oct 27, 2016·Basic & Clinical Pharmacology & Toxicology·Tereza CervenaPavel Rossner
Sep 11, 2017·Environmental Science and Pollution Research International·Magdalena KowalskaAnna Lankoff
Aug 17, 2017·PloS One·Rodolphe CarpentierDidier Betbeder
Jul 31, 2021·Journal of Hazardous Materials·Katherine R LandwehrUNKNOWN WAERP
Aug 28, 2019·Environmental Science & Technology·Katherine R LandwehrUNKNOWN WAERP

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