PMID: 7523891Oct 16, 1994Paper

Comparative mutagenicity of chemicals selected for test in the International Program on Chemical Safety's collaborative study on plant systems for the detection of environmental mutagens

Mutation Research
W F Grant, M F Salamone

Abstract

A review has been made for the four compounds (maleic hydrazide, methyl nitrosourea, sodium azide, azidoglycerol) tested in the International Program on Chemical Safety's collaborative study on plant systems. Maleic hydrazide (MH) is a weak cytotoxic/mutagenic chemical in mammalian tissues and is classified as a class 4 chemical. In contrast, with few exceptions such as Arabidopsis, MH is a potent mutagen/clastogen in plant systems. The difference in its response between plant and animal tissue is likely due to differences in the way MH is metabolized. MH appears to be noncarcinogenic and has been given a negative NCI/NTP carcinogen rating. Methyl nitrosourea (MNU) is a toxic, mutagenic, radiomimetic, carcinogenic, and teratogenic chemical. It has been shown to be a mutagen in bacteria, fungi, Drosophila, higher plants, and animal cells both in vitro and in vivo. MNU is a clastogen in both animal and human cell cultures, plant root tips and cell cultures inducing both chromosome and chromatid aberrations as well as sister-chromatid exchanges. Carcinogenicity has been confirmed in numerous studies and involves the nervous system, intestine, kidney, stomach, bladder and uterus, in the rat, mouse, and hamster. MNU produces stage-s...Continue Reading

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Citations

Jun 19, 1998·Mutation Research·W F Grant, E T Owens
Apr 20, 2005·Reviews on Environmental Health·Te-Hsiu MaElizabeth Owens
Jun 4, 2011·Genetics and Molecular Biology·Carlos Alvarez-MoyaRosa María González Montes
Jul 5, 2007·Journal of Zhejiang University. Science. B·Irulappan Ragunathan, Natarajan Panneerselvam
Jan 1, 2014·International Scholarly Research Notices·Waseem AhmadMohammad Iqbal Lone
Apr 25, 2015·PloS One·Govinda RizalWilliam Paul Quick
Dec 2, 2004·Mutation Research·Paul A White, Larry D Claxton
Nov 2, 2019·Journal of Tissue Engineering and Regenerative Medicine·Lousineh ArakelianValérie Vanneaux
Feb 6, 2004·Environmental Research·L MarcanoX Montiel

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