Comparative neurochemical investigation of tardive dyskinesia and neuroleptic-induced chronic parkinsonism

Psychiatry Research
M AratóA Béla


Cerebrospinal fluid (CSF) homovanillic acid (HVA), cyclic adenosine 3', 5'-monophosphate (cAMP), and serum prolactin were measured in schizophrenic male patients with tardive dyskinesia (TD) and in those exhibiting the symptoms of chronic neuroleptic parkinsonism (P). The patients (nine TD and eight P) were chronic paranoid schizophrenics. Levels of HVA in CSF were found to be significantly higher in the TD group. Normal prolactin levels were observed in both groups and are indicative of tolerance developed in the hypothalamic tuberoinfundibular dopaminergic system.


Dec 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·A V Mackay, G P Sheppard
Mar 22, 1979·Psychopharmacology·M B BowersD Tarsy
Dec 5, 1970·Lancet·P FlemingK R Hunter
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Oct 1, 1980·The American Journal of Psychiatry·D C Moore, M B Bowers
Jun 1, 1981·Psychiatry Research·M B Bowers, G R Heninger
Aug 1, 1980·Psychological Medicine·T KidgerP J Taylor

Related Concepts

Cyclic AMP, (R)-Isomer
Dyskinesia, Medication-Induced
Homovanillic Acid
Atherosclerotic Parkinsonism
Phenylacetic Acids
Delusional Disorder
Antipsychotic Effect

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