Comparative oral bioavailability advantage from curcumin formulations

Drug Delivery and Translational Research
Bhushan MunjalArvind Kumar Bansal

Abstract

The aim of the present study was to study the oral bioavailability of seven different formulations of curcumin (CRM). CRM formulations viz. aqueous suspension, micronized suspension, nanosuspension, amorphous solid dispersion, hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex, combination with piperine, and spray-dried CRM-milk composite were compared for oral bioavailability in male Sprague-Dawley rats at a CRM dose of 250 mg/kg body weight using a validated high-performance liquid chromatography method. Aqueous suspension provided a C max and AUC(0 - t) of 28.9 ng/ml and 26.9 ng h/ml, respectively. In comparison, statistically significant increase in the oral bioavailability was obtained with the nanosuspension, HP-β-CD inclusion complex, and amorphous solid dispersion with 251%, 567%, and 446% increase in terms of AUC(0 - t) and 405%, 415%, and 270% in terms of C max. However, no significant increase in AUC(0 - t) and C max was observed with piperine and micronized suspension. The milk composite reduced the oral bioavailability of CRM (10% and 37% in terms of AUC(0 - t) and C max). A statistically significant increase in the T max was observed with piperine and in HP-β-CD complex, while the T max was reduced for nanos...Continue Reading

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Citations

May 23, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yogesh B PawarArvind K Bansal
Jul 31, 2012·International Journal of Pharmaceutics·Yogesh B PawarArvind Kumar Bansal
Mar 19, 2016·Drug Metabolism Reviews·Mohd Yaseen MalikJawahar Lal
Apr 20, 2013·Molecular Pharmaceutics·Grace A IlevbareLynne S Taylor
Jan 1, 2012·Pharmaceutics·Yogesh B PawarArvind K Bansal
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Palanivel GanesanDong-Kug Choi

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