Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation

Transcription
Aneeshkumar G ArimbasseriRichard J Maraia

Abstract

In eukaryotes, RNA polymerase (RNAP) III transcribes hundreds of genes for tRNAs and 5S rRNA, among others, which share similar promoters and stable transcription initiation complexes (TIC), which support rapid RNAP III recycling. In contrast, RNAP II transcribes a large number of genes with highly variable promoters and interacting factors, which exert fine regulatory control over TIC lability and modifications of RNAP II at different transitional points in the transcription cycle. We review data that illustrate a relatively smooth continuity of RNAP III initiation-elongation-termination and reinitiation toward its function to produce high levels of tRNAs and other RNAs that support growth and development.

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Citations

Aug 7, 2017·Wiley Interdisciplinary Reviews. RNA·Richard J MaraiaMaria R Conte
Feb 23, 2020·Journal of Virology·Gwenny CackettFinn Werner
Aug 31, 2017·Acta Neuropathologica Communications·Kushal J Rohilla, Keith T Gagnon
Mar 12, 2017·Biomolecules·Richard J Maraia, Aneeshkumar G Arimbasseri
Nov 26, 2015·Nature·Niklas A HoffmannChristoph W Müller
Nov 26, 2015·Nature·Richard J Maraia, Keshab Rijal
Feb 9, 2017·Scientific Reports·Alexandra Søgaard HelboKirsten Grønbæk
Dec 5, 2015·RNA Biology·Aneeshkumar G Arimbasseri, Richard J Maraia
Apr 10, 2016·The FEBS Journal·Niklas A HoffmannChristoph W Müller
Apr 22, 2017·Nature Communications·Phong Lan Thao TranVirginia A Zakian
Nov 26, 2020·Nucleic Acids Research·Masatoshi WakamoriTakashi Umehara
Mar 30, 2021·Frontiers in Microbiology·Ana Rita GuimarãesManuel A S Santos
Apr 4, 2021·Journal of Molecular Biology·Matthew S VerosloffJulius B Lucks
Nov 5, 2021·Nature Communications·Zhong ChenQianben Wang

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