Comparative oxygen radical formation and toxicity of BDE 47 in rainbow trout cell lines.

Marine Environmental Research
Jing ShaoEvan P Gallagher

Abstract

The polybrominated diphenyl ethers (PBDEs) constitute a class of flame retardants whose residues have markedly increased in fish and human tissues during the last decade. In particular, the levels of certain PBDE congeners in salmon have raised concern regarding potential risks associated with dietary PBDE exposures. However, little is known regarding PBDE-mediated cell injury in relevant in vitro cell models. We conducted a comparative study of oxyradical production and cell injury in rainbow trout gill (RTgill-W1) and trout liver cells (RTL-W1) exposed to 2,2',4,4'-tetrabromodiphenyl ether (BDE 47), a predominant BDE residue found in fish tissues such as salmonids. Exposure to low micromolar concentrations of BDE 47 elicited a significant loss in RTgill-W1 and RTL-W1 cell viability as measured by alamarBlue assay. The dose-response of BDE toxicity differed among the two cell lines, with the RTL-W1 liver cells showing greater resistance to toxicity at lower BDE 47 doses, but a more dramatic loss of viability relative to gill cells when challenged with higher (50 microM) doses. The sensitivity of the trout liver cells at higher BDE 47 exposures was reflected by a higher basal production of oxygen radical production by 6-carboxy...Continue Reading

Citations

Feb 3, 2009·In Vitro Cellular & Developmental Biology. Animal·L E J LeeN C Bols
Dec 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Suping C HuangLucio G Costa
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Feb 11, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Andrew YehEvan P Gallagher
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Feb 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marília Cristina Oliveira SouzaFernando Barbosa

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