Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

Barry RockxBart L Haagmans


The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.


May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Xinghuo PangDaniel R Feikin
Feb 26, 2004·Nature Medicine·Bart L HaagmansAlbert D M E Osterhaus
Feb 9, 2010·PLoS Pathogens·Saskia L SmitsBart L Haagmans
Mar 27, 2015·Journal of Virology·Bart L HaagmansAlbert D M E Osterhaus
Jan 30, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Victor M CormanChristian Drosten
Feb 9, 2020·Nature Communications·Mathilde RichardSander Herfst
Feb 20, 2020·The New England Journal of Medicine·Lirong ZouJie Wu
Feb 23, 2020·The Lancet. Respiratory Medicine·Zhe XuFu-Sheng Wang
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Mar 3, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sufang TianShu-Yuan Xiao
Mar 7, 2020·Gastroenterology·Fei XiaoHong Shan
Apr 3, 2020·MMWR. Morbidity and Mortality Weekly Report·Anne KimballUNKNOWN CDC COVID-19 Investigation Team
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Vincent J MunsterEmmie de Wit

❮ Previous
Next ❯


May 20, 2020·The FEBS Journal·Oleg O Glebov
Jun 5, 2020·American Journal of Primatology·Wesley José SantosSimone Baldini Lucheis
Jun 4, 2020·Pathogens·Sabari Nath Neerukonda, Upendra Katneni
Jun 24, 2020·Microbial Biotechnology·Harald Brüssow
May 22, 2020·European Journal of Immunology·Huibin LvChris K P Mok
Jun 26, 2020·American Journal of Primatology·Michael J C Reid
Jun 5, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert J Mason
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Jul 15, 2020·Veterinary Pathology·Robert Jan MolenaarWim H M van der Poel
Jun 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley L St John, Abhay P S Rathore
May 15, 2020·Nature·Sin Fun SiaHui-Ling Yen
Jul 14, 2020·Nature·Ann M ArvinHerbert W Virgin
Aug 5, 2020·The Journal of Experimental Medicine·Benjamin IsraelowAkiko Iwasaki
Jul 9, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Riccardo SarzaniFrancesco Spannella
Jul 22, 2020·The FEBS Journal·Wei LiGuangshuo Ou
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Jul 1, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Nicola ClementiNicasio Mancini
Sep 1, 2020·Therapeutic Advances in Respiratory Disease·Stefano BusaniMassimo Girardis
Aug 7, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julie A Bastarache
Aug 25, 2020·Cellular and Molecular Bioengineering·Jhinuk Basu MullickJanak Gaire
Sep 12, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rafal Butowt, Christopher S von Bartheld
Sep 17, 2020·Human Vaccines & Immunotherapeutics·Idris Nasir AbdullahiAbdurrahman El-Fulaty Ahmad
Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Li Eon Kuek, Robert J Lee
Jul 3, 2020·The Indian Journal of Medical Research·Sreelekshmy MohandasRaman R Gangakhedkar
Jun 20, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Nadia OreshkovaArjan Stegeman
May 27, 2020·American Journal of Clinical Pathology·Miroslav SekulicNavid Sadri
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Masaki ImaiYoshihiro Kawaoka
Sep 5, 2020·Journal of Medical Virology·Hassan M AbbasLuma A Al Khames Aga
Aug 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Joana DamasHarris A Lewin
Sep 12, 2020·Cell Research·Shuai MaGuang-Hui Liu
Aug 28, 2020·Frontiers in Medicine·Farhana Rumzum BhuiyanMahmudul Hasan
Jul 22, 2020·Nature Reviews. Cardiology·Masataka NishigaJoseph C Wu
Jul 24, 2020·Viruses·Nikolaus OsterriederJakob Trimpert
Sep 29, 2020·Frontiers in Immunology·Inmaculada Sanclemente-AlamanUlises Gómez-Pinedo
Sep 15, 2020·Frontiers in Public Health·Jingchun FanShisan Bao
Aug 1, 2020·Science·Nicholas J Matheson, Paul J Lehner

❮ Previous
Next ❯

Methods Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
Barry RockxBart L Haagmans
Journal of Pharmaceutical Analysis
Xiaowei LiShemin Lu
Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Wang-Huei ShengPo-Ren Hsueh
© 2021 Meta ULC. All rights reserved