PMID: 1209651Nov 1, 1975Paper

Comparative percutaneous absorption of pyrithiones

Toxicology
D Howes, J G Black

Abstract

The percutaneous absorption of 3H or 35S labelled pyridine-2-thione-N-oxide (PT) through the skin of rat, rabbit and guinea pigs in vivo is reported. The sodium (Na) zinc (Zn) and zirconium (Zr) derivatives of PT were studied and the effects of duration of contact and concentration of the NaPT and ZnPT in test solutions were examined. Shampoo test solutions containing the isotopically labelled PT were applied to the skin of the animals. The skins were then rinsed, the treated areas of skin protected and excreta were monitored for the isotope for 2 days after treatment. Penetration was calculated from the amounts of isotope in the excreta. Further groups of animals were treated with test solutions applied under occlusive patches for 6 h before rinsing the skin. The turnover of Na and ZnPT in the three species after intraperitoneal and subcutaneous injection was measured. All three species rapidly excreted the injected isotope principally via the urine. The comparative penetration of the three PT samples was Na greater than Zr greater than Zn from all treatments. The comparative permeability of the animals' skins to these PTs was rabbit greater than rat greater than guinea pig. NaPT penetration was found to be dependent upon dura...Continue Reading

Citations

Dec 1, 1992·Biological Trace Element Research·S GhoshG Talukder
Jun 1, 1995·Journal of Toxicology and Environmental Health·S C FaganG G Brown
Mar 23, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sarah D Lamore, Georg T Wondrak
Jan 1, 1978·Clinical Toxicology·J G Black, D Howes
Jun 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sarah A TozerJ F Nash
Feb 1, 1977·Food and Cosmetics Toxicology·S A Ziller
Apr 25, 2019·Toxicological Research·Dong Sik JungHyung Gun Kim
Apr 6, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ann ZollerJason Price
Jun 17, 2019·Skin Pharmacology and Physiology·Allison K RushGerald B Kasting

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