Comparative pharmacokinetic studies of ornidazole and metronidazole in man

D E Schwartz, F Jeunet


Pharmacokinetic characteristics of ornidazole and metronidazole were compared in man. Both drugs were labelled with 14C in the imidazole ring at position 2. Four healthy volunteers were given an oral dose of 750 mg of one of the drugs, followed 2--4 weeks later by the same dose of the other. The same technique for determining the unchanged compound was used for both drugs. Results may be summarized as follows: mean peak concentrations in the plasma of 10.9 mug/ml for ornidazole and of 12.3 mug/ml for metronidazole were reached 2--4 h and 30--60 min after administration, respectively; both drugs showed the same volume of distribution. Their binding to human plasma proteins was less than 15%; the mean half-life of elimination from the plasma was 14.4 h for ornidazole and 8.4 h for metronidazole; the mean radioactivity recovered from the urine and faeces during the first 5 days was 85% of the dose for ornidazole and 91% for metronidazole, the major proportion in each case being excreted in the urine; the radioactivity found in the faeces was 22.1% of the dose for ornidazole and 13.9% for metronidazole.


Jan 1, 1989·European Journal of Clinical Pharmacology·F F HorberF J Frey
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·P E NokerS D Wagoner
Jan 1, 1986·European Journal of Clinical Pharmacology·S LoftP B Andreasen
Jan 1, 1987·European Journal of Clinical Pharmacology·A TurcantM Cavellat
Jan 1, 1983·European Journal of Clinical Pharmacology·I AmonF Nagel
Jan 1, 1986·European Journal of Clinical Pharmacology·A Rubenson, A Rosetzsky
Sep 6, 2001·Diseases of the Colon and Rectum·F FriedenbergG M Levine
May 1, 1981·Mutation Research·C E Voogd
Feb 1, 1982·Journal of Toxicology and Environmental Health·H S Buttar
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·E J GoldsteinS M Finegold
May 1, 1981·Antimicrobial Agents and Chemotherapy·I Nilsson-EhleP Nilsson-Ehle
May 1, 1982·Antimicrobial Agents and Chemotherapy·F J NottenF H Mikx
Aug 1, 1977·The British Journal of Venereal Diseases·I MathesonB Bjorkvoll
Jan 11, 2013·Biological & Pharmaceutical Bulletin·Junichi IidaKiyomi Ito
Feb 8, 2011·Chemical & Pharmaceutical Bulletin·Shukla Raj KumarTiwari Akanksha
Jun 3, 2009·Journal of Periodontology·Liqiang YuDongsheng Wang
Jan 1, 1980·Scandinavian Journal of Infectious Diseases·K AlestigE Arnold
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·E VingeE Lunell
Jul 9, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xin WangMahmoud S Ahmed
Sep 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E SchwartzG Oesterhelt
Apr 25, 2007·Drug Delivery·Ozgen OzerKamil Köseoglu
Apr 1, 1977·Journal of Pharmaceutical Sciences·J J Vallner
Jul 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R Jones, T G Cooper
Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman
Dec 18, 2013·The Journal of Pharmacy and Pharmacology·Cristiane de C BergamaschiFrancisco C Groppo
Oct 1, 1980·British Journal of Obstetrics and Gynaecology·S A Seligman, A T Willis
Dec 4, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Toshiyuki KudoKiyomi Ito
Jan 13, 2018·Future Microbiology·Paul Nyirjesy, Jane R Schwebke
Apr 11, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jiangbo DuDafang Zhong
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina Pyka-PająkMałgorzata Dołowy
Nov 1, 1981·Drug Intelligence & Clinical Pharmacy·M H Stranz, W E Bradley
Aug 1, 1982·Acta Pharmacologica Et Toxicologica·C Gjerløff, E Arnold
Sep 23, 2018·Environmental Science and Pollution Research International·Rahil ChangotraLalit Varshney

Related Concepts

Serum Proteins
Bayer 5360
Plasma Protein Binding Capacity

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.