Comparative pharmacokinetics of an injectable cephalexin suspension in beef cattle

Research in Veterinary Science
S Waxman DovaM Rebuelto

Abstract

This study describes and compares the pharmacokinetics of a single 7.5mg/kg dose of cephalexin monohydrate oil-based 20% suspension after its administrations to six cows by the intramuscular (i.m.) and subcutaneous (s.c.) routes, and to five calves by the i.m. route. Significantly (P<0.05) higher peak plasma concentrations (5.6+/-0.79microg/ml versus 3.93+/-1.24microg/ml) and lower half-life (1.81+/-0.56h versus 4.21+/-0.82h) and mean residence time (4.12+/-1.07h versus 6.63+/-0.85h) were obtained after i.m. administration when compared to the s.c. administration to cows. No differences were found between pharmacokinetic parameters calculated for cows and calves. Cephalexin plasma concentrations remained above 0.5-0.75microg/ml for 11-14h and 8-9h after the s.c. and i.m. administrations, respectively. Thus, route of administration may be an important issue to be considered when calculating dosage schedules for successful treatments and safe withdrawal times for veterinary medicines.

References

Sep 1, 1973·Antimicrobial Agents and Chemotherapy·G Ziv, F G Sulman
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Pyörälä
Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·M Gips, S Soback
Nov 14, 1997·Journal of Veterinary Pharmacology and Therapeutics·D Concordet, P L Toutain
Feb 7, 1998·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Räisänen
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Apr 30, 2002·International Journal of Antimicrobial Agents·Niels Frimodt-Møller
Mar 20, 2004·Nature Reviews. Microbiology·George L Drusano
Aug 4, 2004·Veterinary Microbiology·P J Rajala-SchultzB C Love
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·Q A McKellarD G Jones
Nov 30, 2005·Journal of the American Veterinary Medical Association·Butch KuKanichJim E Riviere

❮ Previous
Next ❯

Citations

Apr 7, 2016·Advances in Pharmacological Sciences·Verónica KreilMarcela Rebuelto
Oct 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·L AmbrosM Rebuelto
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·A MonfrinottiM Rebuelto
May 17, 2017·Journal of the American Veterinary Medical Association·Danielle A MzykGeof W Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.