Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Beilei XuGuijun Zhang

Abstract

An LC-MS/MS method was developed for simultaneous analysis of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine of Gegenqinlian Decoction (GQD) and active components alignment (ACA) in rat plasma using hesperidin as the internal standard (I.S.). Chromatography was performed using a C18 column, with gradient elution with 1% acetic acid-0.001 mol/L ammonium acetate and acetonitrile at 0.2 ml/min. All analytes including I.S. were monitored under positive ionization conditions by selected reaction monitoring with an electrospray ionization source. The optimized mass transition ion-pairs (m/z) for quantitation were 471/297 for puerarin, 471/255 for daidzin, 447/271 for baicalin, 823/453 for glycyrrhizic acid, 419/257 for liquiritin, 336/320 for berberine, 352/336 for palmatine, 338/322 for jateorhizine and 611/303 for hesperidin. The calibration curves were linear over the concentration ranges from 0.15-63.0 to 6.3-6340.0 ng/mL. Intra-day and inter-day precisions (RSD%) were within 15.0%, and accuracy (RE%) ranged from -7.4 to 13.2%. The extraction recoveries were ranged from 60.4 to 93.3%. The proposed method was further applied to compare the pharmacokinetics of all analytes followin...Continue Reading

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Citations

Apr 3, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jing ZhangLijie Zhai
Nov 4, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Qun ZhaoLichun Feng
Feb 23, 2019·Journal of Separation Science·Jiahui WangNing Zhang
Aug 4, 2019·Pharmaceutics·Robert AncuceanuVlad Negulescu
May 25, 2021·Frontiers in Pharmacology·Jing-Ze LuBing-Liang Ma
Jun 5, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qinmei LiHongbin Si

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