Comparative pharmacokinetics of the three echinocandins in ICU patients.

The Journal of Antimicrobial Chemotherapy
Efstratios MainasJoseph Meletiadis

Abstract

We conducted a prospective study in ICU patients of two tertiary hospitals in order to determine basic pharmacokinetic (PK) parameters, associated variation and target attainment rates for anidulafungin, micafungin and caspofungin. Serum samples from patients treated for 7 days with the standard doses of anidulafungin (N = 13), micafungin (N = 14) or caspofungin (N = 7) were analysed by validated chromatographic methods. PK parameters determined with non-compartmental analysis were correlated with demographic, laboratory and disease severity characteristics. The percentages of patients attaining drug exposures described in the summary of product characteristics (SmPC) documents and preclinical PK/PD targets for stasis were estimated. The median (range) AUC24 was 101.46 (54.95-274.15) mg·h/L for anidulafungin, 79.35 (28.00-149.30) mg·h/L for micafungin and 48.46 (19.44-103.69) mg·h/L for caspofungin. The interindividual variability of anidulafungin, micafungin and caspofungin AUC24 was 46%-58%, attributed mainly to variability in volume of distribution (V), clearance (CL) and in both V and CL, respectively. Significant correlations were found between anidulafungin AUC24 and BMI (rs = -0.670, P = 0.012) and liver enzymes (rs = 0....Continue Reading

References

May 18, 2004·Journal of Clinical Pharmacology·James A DowellTim Henkel
Sep 24, 2005·Clinical Pharmacokinetics·Sarayut JanmahasatianBruce Green
May 26, 2007·The Journal of Antimicrobial Chemotherapy·T H NguyenM A Weigand
Apr 14, 2010·Antimicrobial Agents and Chemotherapy·D AndesA Lepak
Oct 1, 2011·European Journal of Drug Metabolism and Pharmacokinetics·N UndreE Baraldi
Jan 4, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O A CornelyUNKNOWN ESCMID Fungal Infection Study Group
Jan 22, 2013·Antimicrobial Agents and Chemotherapy·Ping LiuBharat Damle
Jun 5, 2013·Antimicrobial Agents and Chemotherapy·Stefan WeilerRomuald Bellmann
Oct 30, 2013·Antimicrobial Agents and Chemotherapy·Marjolijn J P van WanrooyJan-Willem C Alffenaar
Jun 4, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Nasrullah UndrePaul Stevenson
Aug 21, 2014·The Journal of Antimicrobial Chemotherapy·E W MuilwijkR J M Brüggemann
May 13, 2015·Antimicrobial Agents and Chemotherapy·Vincent J LempersRoger J Brüggemann
Aug 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elie F Berbari Infectious Diseases Society of America
Oct 21, 2016·Intensive Care Medicine·Jason A RobertsJeffrey Lipman
Nov 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel Aguilar-ZapataVidmantas Petraitis
Dec 19, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Sep 10, 2016·The Journal of Antimicrobial Chemotherapy·Vincent JullienUNKNOWN EMPIRICUS Trial Study Group
Nov 18, 2016·Antimicrobial Agents and Chemotherapy·Kim C M van der ElstJan-Willem C Alffenaar
Jan 16, 2017·The Journal of Antimicrobial Chemotherapy·H DupontP Montravers
Oct 4, 2017·Antimicrobial Agents and Chemotherapy·J M BoonstraJ W C Alffenaar
Jan 6, 2018·The Journal of Antimicrobial Chemotherapy·Frederic LamothThierry Calandra
May 2, 2018·Antimicrobial Agents and Chemotherapy·Roeland E WasmannRoger J Brüggemann
May 8, 2019·Antimicrobial Agents and Chemotherapy·S LuqueS Grau
Jul 23, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·D V Pérez CivantosV Jerez Gómez-Coronado
Nov 30, 2019·Scientific Reports·Silke GastineBjörn Ellger

❮ Previous
Next ❯

Citations

Apr 21, 2021·Infection·Tiziana GasperettiRomuald Bellmann
Jan 23, 2021·Acta Anaesthesiologica Scandinavica·Pekka YlipalosaariHannu Syrjälä

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.