Comparative Pharmacokinetics of three major bioactive components in rats after oral administration of Typhae Pollen-Trogopterus Feces drug pair before and after compatibility.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Huiting ZengJin-Ao Duan

Abstract

Typhae Pollen (TP) and Trogopterus Feces (TF) are well-known traditional medicine in china which widely used for thousands of years as drug pair called Shixiao San for treatment of blood stasis syndrome, specially shown great efficacy in gynecological disease. Typhaneoside, vanillic acid and p-coumaric acid are the main bioactive components of Typhae Pollen. This study was carried out for comparing the pharmacokinetic profile of these three major bioactive components in rats after oral administration of Typhae Pollen-Trogopterus Feces (TP-TF) drug pair before and after compatibility. A sensitive and rapid UPLC-TQ/MS method has been developed for simultaneous quantification of the three main bioactive compounds in blood at different time points after oral administration of Typhae Pollen (TP) and the combination with Trogopterus Feces (TF). There were significant differences of C(max), T(max), T(1/2) and AUC(0~t) for three bioactive compounds among the groups, for typhaneoside with the most highest plasma concentration of 370.86 ± 315.71 ng/mL and more longer T(max) in TP-TF co-decoction group (C(M)); for vanillic acid, TP-TF co-decoction group (C(M)) had a good absorption with C(max) (3870.99 ± 2527.99 ng/mL) and T(max) (1.47 ± ...Continue Reading

References

Feb 7, 2003·Current Medicinal Chemistry·Benjamin Gilbert, Lucio Ferreira Alves
Jan 4, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ke LiuXinjie Guo
Sep 3, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xinjie ZhaoGuowang Xu
Oct 17, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L ChenX-Q Liu
Dec 4, 2009·Fitoterapia·Nian-Yun YangJian-Guo Jiang
Apr 21, 2010·Journal of Natural Products·Jun ZhaoYong-Xian Cheng
Jul 14, 2010·The American Journal of Chinese Medicine·Shulan SuYuping Tang
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ZhouJin Zhang
Nov 26, 2010·Natural Product Research·Nian-Yun YangJin-Ao Duan
Jul 30, 2011·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·UNKNOWN National Association of EMS Physicians
Jul 24, 2012·Journal of Pharmaceutical and Biomedical Analysis·Peidong ChenAnwei Ding
Aug 9, 2012·Journal of Ethnopharmacology·Shengpeng WangYitao Wang
Nov 28, 2013·Complementary Therapies in Medicine·Young-Jae ParkYoung-Bae Park
Jan 1, 2015·Beilstein Journal of Organic Chemistry·Soyoon BaekSang Hee Shim

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Citations

Jan 23, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xie-An YuYan-Xu Chang
May 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Shuhan ChuLixin Ding
Nov 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lingna WuChunhua Xia

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