Comparative pharmacokinetics of three triterpene acids in rat plasma after oral administration of Poria extract and its formulated herbal preparation: GuiZhi-FuLing capsule

Feng XiaoYing Jia


A sensitive liquid chromatographic-mass spectrometric technique coupled with liquid-liquid extraction method was developed and validated for simultaneous determination of dehydro-tumulosic acid, tumulosic acid and polyporic acid C in rat plasma. The analytes were separated on a Kromasil C(18) column with a total running time of 12.5 min. Author had compared the pharmacokinetics of dehydro-tumulosic acid, tumulosic acid and polyporic acid C after oral administration of the extract of Poria and its formulated herbal preparation (GuiZhi-FuLing capsule). The improved pharmacokinetic profiles of the three compounds were found in the GuiZhi-FuLing capsule, indicating the more effective absorption and the slower elimination, compared with the Poria extract. Furthermore, this study revealed that as far as the Poria extract was concerned, it is very valuable to be used as a clinical instruction of GF capsule.


Apr 1, 1996·Chemical & Pharmaceutical Bulletin·H NukayaK Tsuji
Sep 1, 1996·Japanese Journal of Pharmacology·Y OkuiA Niijima
Dec 1, 1995·The Journal of Pharmacy and Pharmacology·S TakedaM Maruno
Oct 1, 1996·Journal of Natural Products·M J CuéllaJ L Ríos
May 31, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zonghua SongKelvin Chan
Aug 28, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Y ShimadaK Terasawa
Oct 27, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M H OhJ H Cho
May 26, 2005·Biochemical and Biophysical Research Communications·Leslie GapterKa-yun Ng
Nov 25, 2006·Journal of Ethnopharmacology·Takako NakagawaYutaka Shimada
May 10, 2007·Journal of Natural Products·Toshihiro AkihisaHoyoku Nishino
Jul 21, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhenyu ZhuYifeng Chai
Sep 11, 2010·Journal of Pharmaceutical and Biomedical Analysis·Li-Na FangKai-Shun Bi

❮ Previous
Next ❯


Oct 28, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yosuke MatsubaraKenshi Yamasaki
Apr 29, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Hui-Fei WuWei-Rong Li
Nov 30, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShenXueqiong Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.