Aug 1, 1977

Comparative pharmacology of cefaclor and cephalexin

Antimicrobial Agents and Chemotherapy
O M KorzeniowskiM A Sande


Two cephalosporin antibiotics, cefaclor and cephalexin, were administered orally to healthy, adult male volunteers for comparison of their pharmacological properties. In doses of 250 mg orally, cefaclor produced a peak serum concentration of 6.01 +/- 0.55 (standard deviation [SD]) mug/ml compared with 9.43 +/- 2.36 mug/ml for cephalexin (P < 0.01). The half-lives were 0.58 +/- 0.07 (SD) h and 0.80 +/- 0.12 (SD) h, and elimination constants were 1.22 +/- 0.15 and 0.88 +/- 0.13 h(-1) for cefaclor and cephalexin, respectively (P < 0.001). Neither drug showed accumulation over the dosing period, and both were well tolerated.

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Mentioned in this Paper

Cephalexin, Monosodium Salt, (6R-(6alpha,7beta))-Isomer
Oral Cavity
Intestinal Absorption
Cephalosporanic Acids

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