Comparative phytochemical, cytotoxicity, antioxidant and haemostatic studies of Taraxacum officinale root preparations

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Dariusz JędrejekBeata Olas

Abstract

Although the majority of potentially bioactive components of dandelion root have been described, revealing the presence of hydroxycinnamic acids (HCAs) and sesquiterpene lactones (SLs), new compounds are still being discovered, an example of which are the recently characterized 4-hydroxyphenylacetate inositol esters (PIEs). In this work, the dandelion root was separated into five preparations (A-E) differing in chemical content. A detailed LC-MS and chemical investigation of dandelion fractions allowed the identification of about 100 phytochemicals, including new compounds for the genus Taraxacum, and the plant kingdom, such as amino acid-SL adducts. In the DPPH● test, two preparations characterized by high content of HCAs (D and E) showed the highest free radical scavenging activity, while other demonstrated weaker action. In turn, in blood plasma, the best overall protective effect against oxidation by H2O2/Fe was obtained in the presence of preparations A (SL-amino acid adducts enriched fraction) and C (PIEs enriched fraction). A stronger anticoagulant effect was demonstrated for two preparations enriched with HCAs (D and E). None of dandelion root preparations caused the lysis of blood platelets, at all tested range (0.5-50...Continue Reading

Citations

Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li DuanLong Guo
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bernadetta LisBeata Olas
Mar 9, 2021·Food & Function·Paula Garcia-OliveiraJesús Simal-Gandara
Oct 13, 2021·Scientific Reports·Dorota Adamczyk-SzabelaWojciech M Wolf

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