PMID: 16505759Mar 1, 2006Paper

Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites

Gastroentérologie Clinique Et Biologique
Anne LenaertsGaston Ligny

Abstract

To study the usefulness of the combination of clonidine--spironolactone in refractory ascites. Twenty cirrhotic patients with refractory ascites were randomly assigned to receive repeated large volume paracentesis plus intravenous albumin (group 1), or a combination of clonidine (0.075 mg twice daily) and spironolactone (200 to 400 mg daily) (group 2). During the first hospitalisation,, the mean weight loss in group 1 was higher than in group 2 (12.4 +/- 3.2 versus 4.3 +/- 1.1 kg, P < or = 0.01). Mean stay in hospital was shorter in group 2 (20 +/- 1.5 versus 10 +/- 2.8 days; P < or = 0.01). Paracentesis did not induce changes in neuro-hormonal measurements. Oppositely, clonidine induced a decreased sympathetic activity, an increased glomerular filtration rate and a delayed reduction of the renin-aldosterone levels. During the follow-up in group 1, the number of rehospitalisations for ascites was higher than in group 2 (37 versus 3; P < or = 0.01), and the mean time to the first readmission was shorter (10 +/- 2.7 versus 23.7 +/- 5.6 days; P < or = 0.01). The total duration spent in hospital were similar in both groups. Paracentesis is more effective for short-term treatment of ascites but clonidine-spironolactone association m...Continue Reading

References

Oct 1, 1978·The American Journal of Medicine·A P NiarchosI Radichevich
Mar 1, 1992·Drugs·P GinèsJ Rodés
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Jan 1, 1985·Annals of Internal Medicine·D S GoldsteinH R Keiser

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Citations

Sep 12, 2009·Journal of Gastroenterology and Hepatology·Jung Min LeeSang Hoon Ahn
Dec 31, 2008·World Journal of Gastroenterology : WJG·Bahaa Eldeen Senousy, Peter V Draganov
May 17, 2014·World Journal of Gastroenterology : WJG·Salman NusratMohammad F Madhoun
Aug 19, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Meritxell Ventura-CotsJoan Genescà
Feb 20, 2013·The American Journal of Gastroenterology·Virendra SinghAshish Bhalla
May 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce A Runyon, UNKNOWN AASLD Practice Guidelines Committee
Jul 12, 2018·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Dec 31, 2010·American Journal of Therapeutics·Shashideep SinghalSury Anand
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anne LenaertsGaston Ligny
Jan 15, 2009·American Journal of Therapeutics·John C Somberg, Janos Molnar
Sep 18, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Young Seok Kim
May 21, 2009·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Members of Veterans Affairs Hepatitis C Resource Center Program
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Claudia Asenjo LobosStefan Leucht
Oct 23, 2012·American Journal of Therapeutics·Kiran BaikatiSury Anand
Nov 20, 2013·The Cochrane Database of Systematic Reviews·Laila AsmalStefan Leucht
Mar 4, 2008·The International Journal of Artificial Organs·R L MehtaP Murray

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