Comparative Plasma and Interstitial Fluid Pharmacokinetics of Meloxicam, Flunixin, and Ketoprofen in Neonatal Piglets

Frontiers in Veterinary Science
Emma NixonKristen M Messenger

Abstract

Piglet castration and tail-docking are routinely performed in the United States without analgesia. Pain medications, predominately non-steroidal anti-inflammatory drugs, are used in the EU/Canada to decrease pain associated with processing and improve piglet welfare, however, past studies have shown the efficacy and required dose remain controversial, particularly for meloxicam. This study assessed the pharmacokinetics of three NSAIDs (meloxicam, flunixin, and ketoprofen) in piglets prior to undergoing routine castration and tail-docking. Five-day-old male piglets (8/group) received one of 3 randomized treatments; meloxicam (0.4 mg/kg), flunixin (2.2 mg/kg), ketoprofen (3.0 mg/kg). Two hours post-dose, piglets underwent processing. Drug concentrations were quantified in plasma and interstitial fluid (ISF) and pharmacokinetic parameters were generated by non-compartmental analysis. Time to peak concentration (Tmax) of meloxicam, flunixin, and S(-)-ketoprofen in plasma were 1.21, 0.85, and 0.59 h, compared to 2.81, 3.64, and 2.98 h in the ISF, respectively. The apparent terminal half-life of meloxicam, flunixin and S(-)-ketoprofen were 4.39, 7.69, and 3.50 h, compared to 11.26, 16.34, and 5.54 h, respectively in the ISF. If drug ...Continue Reading

References

Sep 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·P JaussaudP Delatour
May 18, 2001·Applied Animal Behaviour Science·A A. TaylorL Braithwaite
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·F Shojaee AliabadiP Lees
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P LeesP L Toutain
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·J L BuurJ E Riviere
May 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
Jul 20, 2010·Veterinary Anaesthesia and Analgesia·Alassane KeitaChristian Guidarini
Oct 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
Mar 15, 2011·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
May 31, 2011·Journal of Animal Science·J-L Rault, D C Lay
Jul 7, 2011·Journal of Veterinary Pharmacology and Therapeutics·T K FosseB Ranheim
Jul 26, 2011·Journal of Veterinary Pharmacology and Therapeutics·L PelligandP Lees
Nov 24, 2011·The Veterinary Journal·Eva NeirinckxChris Vervaet
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·M Kluivers-PoodtL J Hellebrekers
Aug 15, 2013·BMC Veterinary Research·Monique D Pairis-GarciaJohann F Coetzee
Oct 2, 2014·Journal of Veterinary Pharmacology and Therapeutics·M D Pairis-GarciaJ F Coetzee
Jan 6, 2015·Animal : an International Journal of Animal Bioscience·C LonardiF Gottardo
May 12, 2015·Journal of Veterinary Pharmacology and Therapeutics·K M MessengerM G Papich
Apr 14, 2017·Porcine Health Management·Nancy De BriyneDéborah Temple
Nov 17, 2017·Journal of Veterinary Pharmacology and Therapeutics·O L LevionnoisB Ranheim
Dec 12, 2018·Frontiers in Veterinary Science·Abbie V Viscardi, Patricia V Turner
May 28, 2019·Research in Veterinary Science·Jinhyeon YunOlli Peltoniemi

❮ Previous
Next ❯

Citations

Aug 23, 2020·Animals : an Open Access Journal From MDPI·Meredith Sheil, Adam Polkinghorne
Jul 28, 2020·Animals : an Open Access Journal From MDPI·Kristen ReynoldsTerri L O'Sullivan
Sep 18, 2020·BMC Veterinary Research·Emma NixonRonald E Baynes

❮ Previous
Next ❯

Software Mentioned

Excel
Phoenix WinNonLin

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Revista de medicina de la Universidad de Navarra
M EscolarJ Honorato
Expert Opinion on Pharmacotherapy
Brian J GatesNeal M Davies
© 2021 Meta ULC. All rights reserved